Biocompatibility study of different hyaluronan products for intra-articular treatment of knee osteoarthritis

Table 1 HA products used in this study

Brand name (Lot number)	Type	Concentration	Origin	Molecular weight^a
SUPARTZ FX™ (4X7Z01)	Natural HA	10 mg/mL (2.5 mL)	Avian	620–1170 kDa
ORTHOVISC® (N170038B)	Natural HA	15 mg/mL (2 mL)	Fermentation	1000–2900 kDa
SYNVISC® (6RSP017)	Cross-linked HA (protein and DVS)^b	8 mg/mL (2 mL)	Avian	hylan A; 6000 kDa hylan B; > 6000 kDa

^aMolecular weight supplied by the manufacturer
^bHylan A has protein-mediated cross-linking, hylan B is composed of hylan A with additional DVS-mediated cross-linking

ISSN: 1471-2474