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Table 1 Treatment protocol for CRMO

From: A complicated path to the CRMO diagnosis – case of a 9 year old girl whose story comes full circle

First line treatment – NSAIDs:
 Ibuprofen 30–40 mg/kg/day in 3–4 divided doses for 1–3 months
 Naproxen 10-15 mg/kg/day in 2 divided doses for 1–3 months
Second line treatment – Corticosteroids:
 Prednisolone 1–2 mg/kg/day in 1 dose for 5–10 days up to clinical improvement, NSAIDs as the continuation of the therapy;
 In severe cases prednisolone treatment may be prolonged up to 4–6 weeks
Third line treatment – DMARDs
 Sulfasalazine
 Methotrexate
 Bisphosphonates (Pamidronate)
 TNFα-inhibitors