Comparison | RR (95% CI) | No. of participants (studies) | Quality of the evidence |
---|---|---|---|
Vertebral fracture | |||
 Antiresorptive medication vs. Control | 0.59 (0.53 to 0.65) | 21,012 (30 RCTs) | – |
 ZOL vs. Control | 0.34 (0.17 to 0.69) | 657 (1 RCT) a | MODERATE b, |
 ALN vs. Control | 0.54 (0.43 to 0.68) | 2277 (3 RCTs) c | HIGH |
 RISE vs. Control | 0.61 (0.51 to 0.73) | 2645 (5 RCTs) d | MODERATE e |
 Etidronate vs. Control | 0.60 (0.39 to 0.92) | 618 (7 RCTs) f | MODERATE g, |
 Ibandronate (sufficient) vs. Control | 0.52 (0.38 to 0.71) | 2929 (1 RCT) h | MODERATE i, |
 Ibandronate (insufficient) vs. Control | 0.87 (0.69 to 1.11) | 2860 (1 RCT) j | MODERATE k |
 Minodronate vs. Control | 0.44 (0.31 to 0.63) | 674 (1 RCT) l | LOW m |
 Pamidronate vs. Control | 0.33 (0.13 to 0.84) | 90 (1 RCT) n | VERY LOW o |
 Calcitonin vs. Control | 1.02 (0.14 to 7.36) | 157 (3 RCTs) p | VERY LOW q |
 HRT vs. Control | 0.86 (0.29 to 2.52) | 147 (3 RCTs) r | LOW s |
 PTH vs. Control | 0.32 (0.24 to 0.43) | 2632 (4 RCTs) t | MODERATE u |
 Denosumab vs. Control | 0.41 (0.29 to 0.57) | 1654 (2 RCTs) v | MODERATE w |
 RLX vs. Control | 0.58 (0.44 to 0.76) | 2447 (2 RCTs) x | HIGH |
 BZA vs. Control | 0.66 (0.53 to 0.82) | 3857 (1 RCT) y | MODERATE z |
 ALN vs. Denosumab | 0.69 (0.41 to 1.17) | 722 (1 RCT) aa | LOW bb |
 Romosozumab vs. Alendronate | 0.64 (0.49 to 0.84) | 4093 (1 RCT)cc | MODERATEdd |
 RISE vs. Etidronate | 1.12 (0.69 to 1.81) | 433 (1 RCT) ee | MODERATE ff |
 Ibandronate vs. RISE | 1.01 (0.79 to 1.31) | 1228 (1 RCT)gg | HIGH |
 RISE vs. Teriparatide | 1.98 (1.44 to 2.70) | 2070 (2 RCTs) hh | HIGH |
 HRT vs. Etidronate | 0.63 (0.12 to 3.32) | 35 (1 RCT) ii | VERY LOW jj |
Non-vertebral fracture | |||
 ZOL vs. Control | 0.54 (0.32 to 0.91) | 661 (1 RCT)kk | – |
 ALN vs. Control | 0.81 (0.65 to 1.01) | 2027 (1 RCT)ll | – |
 RISE vs. Control | 0.71 (0.54 to 0.92) | 2836 (4 RCTs)mm | – |
 Etidronate vs. Control | 0.95 (0.59 to 1.53) | 395 (4 RCTs)nn | – |
 Ibandronate (sufficient) vs. Control | 1.10 (0.85 to 1.41) | 2929 (1 RCT)oo | – |
 Ibandronate (insufficient) vs. Control (only Hip fracture) | 0.59 (0.26 to 1.31) | 2860 (1 RCT)pp | – |
 Minodronate vs. Control | 0.80 (0.35 to 1.84) | 674 (1 RCT)qq | – |
 Pamidronate vs. Control | 0.33 (0.04 to 3.10) | 100 (1 RCT)rr | – |
 PTH vs. Control | 0.53 (0.36 to 0.78) | 2454 (3 RCTs)ss | – |
 Denosumab vs. Control | 0.45 (0.20 to 1.03) | 952 (1 RCT)tt | – |
 Romosozumab vs. ALN | 0.74 (0.54 to 1.00) | 4093 (1 RCT)uu |  |
 ALN vs. Dmab | 1.49 (0.52 to 4.24) | 722 (1 RCT)vv | – |
 Ibandronate vs. RISE | 1.12 (0.75 to 1.66) | 1134 (1 RCT)gg | – |
 RISE vs. Teriparatide | 1.28 (0.94 to 1.73) | 2070 (2 RCTs)ww | – |
 HRT vs. Etidronate | 0.94 (0.06 to 13.93) | 35 (1 RCT)xx | – |