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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis

Fig. 1

On day 0, Sprague-Dawley rats were anesthetized with isoflurane and injected intraarticularly with 2 mg monoiodoacetate (MIA) and a retrograde neurotracer (2% fluoro-gold in 25 μl of 0.9% saline). They were randomly separated into three groups of non-treatment group, early injection group, and late injection group. In each animal, 1 × 106 PLA cells were injected into the right knee while saline was injected in the left knee as a control. PLA cells were injected on day 7 (early injection group) or 14 (late injection group) after administration of MIA. Rats were euthanized by CO2 at 7, 14, 21 days after MIA administration, and the knee joints and spines were harvested for examination

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