TY - JOUR AU - Collins, Fraser L. AU - Stone, Michael D. AU - Turton, Jane AU - McCabe, Laura R. AU - Wang, Eddie C. Y. AU - Williams, Anwen S. PY - 2019 DA - 2019/07/12 TI - Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels JO - BMC Musculoskeletal Disorders SP - 326 VL - 20 IS - 1 AB - Oestrogen-deficiency induced by menopause is associated with reduced bone density and primary osteoporosis, resulting in an increased risk of fracture. While the exact etiology of menopause-induced primary osteoporotic bone loss is not fully known, members of the tumour necrosis factor super family (TNFSF) are known to play a role. Recent studies have revealed that the TNFSF members death receptor 3 (DR3) and one of its ligands, TNF-like protein 1A (TL1A) have a key role in secondary osteoporosis; enhancing CD14+ peripheral blood mononuclear cell (PBMC) osteoclast formation and bone resorption. Whether DR3 and TL1A contribute towards bone loss in menopause-induced primary osteoporosis however, remains unknown. SN - 1471-2474 UR - https://doi.org/10.1186/s12891-019-2704-z DO - 10.1186/s12891-019-2704-z ID - Collins2019 ER -