Table 9 KOOS changes from baseline (mean (SD)) in the Full Analysis Set Population

Pains

n = 45

16.173 (18.13)

n = 42

16.968 (18.36)

n = 42

20.106 (21.62)

n = 39

20.664 (20.22)

n = 41

21.341 (18.68)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Symptoms

n = 45

11.164 (16.04)

n = 42

10.431 (17.05)

n = 42

13.747 (14.59)

n = 39

12.790 (16.27)

n = 41

14.184 (17.27)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Activity of daily living

n = 45

16.97 (16.08)

n = 42

15.384 (18.49)

n = 42

19.60 (20.80)

n = 39

19.92 (17.72)

n = 41

20.51 (16.82)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Sports/ Recreation function

n = 45

15.963 (19.21)

n = 41

17.31 (27.40)

n = 40

18.65 (28.17)

n = 38

21.930 (26.79)

n = 40

17.563 (24.17)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Quality of life

n = 45

16.898 (26.82)

n = 42

15.774 (25.43)

n = 42

19.643 (26.54)

n = 39

23.077 (26.45)

n = 41

18.902 (29.23)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

KOOS total

n = 45

77.171 (76.99)

n = 42

73.368 (85.49)

n = 42

90.854 (88.37)

n = 39

97.820 (85.82)

n = 41

91.95 (83.47)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001