Table 8 VAS changes from baseline (mean (SD)) in the Full Analysis Set Population

Knee pain at rest

n = 46

−21.7 (23.7)

n = 43

− 20.1 (24.5)

n = 43

− 26.9 (25.1)

n = 39

− 29.9 (24.4)

n = 41

− 29.8 (23.8)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Knee pain while walking

n = 45

− 25.5 (24.0)

n = 42

− 26.9 (24.7)

n = 42

− 30.2 (29.4)

n = 39

− 31.3 (31.1)

n = 40

− 31.5 (31.5)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Patient’s global assessment of disease activity

n = 45

− 22.7 (27.8)

n = 42

− 21.0 (26.4)

n = 42

− 23.9 (28.5)

n = 39

− 30.5 (30.6)

n = 40

− 25.3 (31.5)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001

Investigator global assessment of disease activity

n = 42

− 21.0 (22.3)

n = 40

− 21.4 (25.0)

n = 41

− 23.0 (24.9)

n = 37

− 24.4 (23.9)

n = 37

− 25.8 (25.5)

P-value

< 0.001

< 0.001

< 0.001

< 0.001

< 0.001