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Table 6 Mean T2 relaxation time and standard deviation of relaxation time for patella (median (IQR)) in the Full Analysis Set population

From: Hyaluronan derivative HYMOVIS® increases cartilage volume and Type II collagen turnover in osteoarthritic knee: data from MOKHA study

 

Mean T2 relaxation time (ms)

SD of relaxation time (ms)

Median (IQR) n = 38

p-value

Median (IQR)n = 38

p-value

Whole Patella- whole layer

D180 vs D0

D360 vs D0

2.822 (− 3.872; 8.996)

1.168 (− 7.721; 9.410)

0.403

0.593

0.627 (−3.895; 7.427)

0.236 (− 9.654; 7.812)

0.480

0.960

Whole Patella- top layer

D180 vs D0

D360 vs D0

4.446 (−6.977; 16.697)

4.937 (− 10.051; 21.672)

0.320

0.327

6.644 (− 21.994; 20.796)

1.413 (− 16.726; 28.354)

0.593

0.603

Whole Patella- middle layer

D180 vs D0

D360 vs D0

1.236 (−2.881; 6.889)

0.125 (− 6.598; 7.365)

0.356

0.803

0.788 (− 4.667; 6.221)

− 0.333 (− 11.132; 13.976)

0.603

0.870

Whole Patella- bottom layer

D180 vs D0

D360 vs D0

0.202 (− 3.239; 5.418)

− 0.228 (− 2.205; 5.368)

0.545

0.633

1.115 (− 2.416; 5.700)

0.408 (− 4.172; 6.304)

0.320

0.644

Medial trochlea - whole layer

D180 vs D0

D360 vs D0

−2.354 (− 16.342; 4.102)

− 2.429 (− 12.540; 0.968)

0.061

0.019

−1.959 (− 8.472; 1.353)

− 0.818 (− 6.424; 1.126)

0.008

0.107

Medial trochlea - top layer

D180 vs D0

D360 vs D0

−1.768 (− 8.476; 1.722)

− 1.777 (− 9.093; 2.549)

0.027

0.075

−1.774 (− 6.983; 1.804)

− 0.449 (− 5.186; 1.711)

0.023

0.229

Medial trochlea - middle layer

D180 vs D0

D360 vs D0

1.606 (− 14.664; 2.549)

− 1.45 (− 10.896; 0.991)

0.032

0.024

−2.074 (− 9.846; 2.389)

− 0.796 (− 7.151; 0.737)

0.011

0.033

Medial trochlea- bottom layer

D180 vs D0

D360 vs D0

−2.303 (− 21.865; 7.574)

− 1.852 (− 16.764; 0.791)

0.16

0.023

−2.703 (− 13.902; 2.017)

− 1.574 (− 8.096; 2.390)

0.006

0.124

Lateral trochlea - whole layer

D180 vs D0

D360 vs D0

− 2.167 (− 10.398; 0.720)

− 2.107 (− 11.110; 0.938)

0.001

0.006

− 0.804 (− 6.646; 2.799)

− 0.508 (− 3.996; 0.839)

0.110

0.117

Lateral trochlea - top layer

D180 vs D0

D360 vs D0

− 0.410 (− 8.520; 4.261)

0.169 (− 5.191; 7.014)

0.623

0.848

1.069 (− 7.704; 10.070)

0.670 (− 3.756; 8.526)

0.972

0.387

Lateral trochlea - middle layer

D180 vs D0

D360 vs D0

−3.663 (− 11.111; 0.482)

− 2.380 (− 10.532; 0.399)

0.001

0.001

− 1.473 (− 9.228; 0.898)

− 1.547 (− 7.190; − 0.374)

0.009

0.003

Lateral trochlea - bottom layer

D180 vs D0

D360 vs D0

−2.538 (− 26.748; 0.497)

− 2.677 (− 20.622; 0.621)

0.001

0.002

−1.188 (− 8.698; 0.999)

− 2.245 (− 9.955; 1.961)

0.005

0.012