Fig. 5

Histomorphometric analyses with the synovitis grading score of foot and ankle joints in control and MR16–1 treated mice. The synovitis grading scores of MR16–1 treatment group are significantly lower in week 14, 17 and 20 compared with those of control group. Results are expressed as the mean ± standard error (n = 5 mice per group). Representative data are shown from three independent experiments with similar results. **p < 0.01, ***p < 0.001 by two-way ANOVA with Tukey’s multiple comparison test