Fig. 4

Histological images of control and MR16–1 treated groups at week 20. Representative histological images of ankle joint and foot in control group. a is × 40 lower magnification image. b is × 100 higher magnification image. Rectangle shows the higher magnification area. Arrow heads indicate subsequent interosseous ankylosis after synovial proliferation. * indicates entheseal fibrous and cartilaginous ankylosis. Representative histological images of ankle joint and foot in MR16–1 treatment group. c is × 40 lower magnification image. d is × 100 higher magnification image. Rectangle shows the higher magnification area. * indicates entheseal fibrous and cartilaginous ankylosis