Association of serum bone- and muscle-derived factors with age, sex, body composition, and physical function in community-dwelling middle-aged and elderly adults: a cross-sectional study

Table 3 Multiple regression analysis

model		B	SE(B)	β	t	95% CI	p	R²
(a) Sclerostin as dependent variable
1	Sex^a	24.14	2.56	0.52	9.40	(19.08~29.20)	< 0.001	0.267
2	Sex^a	23.13	2.50	0.49	9.24	(18.20~28.06)	< 0.001	0.311
2	Age	0.58	0.14	0.21	4.04	(0.30~0.86)	< 0.001
3	Sex^a	19.71	2.72	0.42	7.23	(14.34~25.08)	< 0.001	0.332
	Age	0.71	0.14	0.26	4.80	(0.42~1.01)	< 0.001
	SOS	0.15	0.05	0.17	2.92	(0.50~0.25)	0.004
4	Sex^a	18.91	2.73	0.40	6.91	(13.52~24.29)	< 0.001	0.342
	Age	0.75	0.14	0.28	5.06	(0.46~1.05)	< 0.001
	SOS	0.14	0.05	0.15	2.64	(0.03~0.24)	0.009
	TRACP5b	−0.02	0.01	−0.11	−2.10	(−0.03~ − 0.001)	0.037
(b) OC as dependent variable
1	TRACP-5b	0.03	0.003	0.63	12.78	(0.03~0.04)	< 0.001	0.404
2	TRACP-5b	0.03	0.003	0.60	12.15	(0.03~0.04)	< 0.001	0.428
2	Sex^a	−2.73	0.81	−0.16	−3.36	(−4.33~ − 1.13)	0.001
3	TRACP-5b	0.03	0.003	0.62	12.46	(0.03~0.04)	< 0.001	0.438
	Sex^a	−2.49	0.81	−0.15	−3.06	(−4.09~ − 0.89)	0.002
	Age	−0.10	0.04	−0.11	−2.23	(−0.19~ − 0.01)	0.026
(c) IGF-1 as dependent variable
1	Age	−1.03	0.22	−0.29	−4.68	(−1.47~ − 0.60)	< 0.001	0.080
2	Age	−0.88	0.22	−0.24	−3.93	(−1.32~ − 0.42)	< 0.001	0.107
2	SOS	0.21	0.07	0.17	2.85	(0.06~0.35)	0.005
3	Age	−0.86	0.22	−0.24	−3.87	(−1.30~ − 0.42)	< 0.001	0.124
	SOS	0.19	0.07	0.16	2.60	(0.04~0.33)	0.010
	BMI	1.58	0.66	0.14	2.38	(0.27~2.89)	0.018

B, partial regression coefficient; SE, standard error; β, standardized partial regression coefficient; t, t-ratio; 95%CI, 95% confidence interval; p, p-value; R², coefficient of determination
BMI, body mass index; IGF-1, insulin-like growth factor-1; OC, osteocalcin; SMI, skeletal muscle mass index; SOS, speed of sound; TRACP-5b, tartrate-resistant acid phosphatase-5b
Multiple regression analysis was performed with serum sclerostin, OC, and IGF-1 as dependent variables, and with age, gender, BMI, SOS, SMI, grip power, gait speed, and TRACP-5b as independent variables
Selection of modelling was done using stepwise method
^a Women = 0, Men = 1

ISSN: 1471-2474