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Table 3 Identification of under- and overexpressed proteins by nanoLC-MS/MS

From: Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Spot No. protein NWa PIb Ratioc p-valued Scoree Peptidef Coverageg
U-1 Actin, cytoplasmic 1 42,052 5.29 4.98 0.00044 338 7 35%
U-2 Fibronectin 266,052 5.46 4.55 0.011 1640 25 22%
U-3 Vitamin D-binding protein 54,526 5.40 2.40 0.000033 8417 26 72%
U-4 Coagulation factor XIII A chain 83,728 5.75 2.33 0.00013 728 14 29%
U-5 Fibrinogen alpha chain 95,656 5.70 2.08 0.00059 17,627 26 44%
U-6 Complement factor H-related protein 1 38,766 7.38 2.06 0.00059 725 6 18%
U-7 Fibrinogen alpha chain 95,656 5.70 2.04 0.0005 10,673 25 42%
D-1 Complement C3 188,569 6.02 −3.19 0.0043 2819 16 21%
D-2 Complement C3 188,569 6.02 −2.84 0.0076 437 7 13%
D-3 Adiponectin 26,511 5.42 −2.50 0.021 59 1 0.17%
D-4 Prothrombin 42,108 5.31 −2.06 0.022 92 4 5%
  1. a; Relative molecular mass, b; Isoelectric point, c; Mean volume ratio of AIS group vs. control group (AIS/Control, −X = 1/X), d; Student’s t-test, e; Based on the MOWSE logarithmic scoring algorithm; a score of ≥ 64 indicates significance, f; Number of peptide fragments matching the candidate protein, g; Percentage of sequences hit for registered full sequence