Table 4 Pre-Radiographic Structural Features at 1 Years Prior to Disease Onset Associated with Accelerated Knee Osteoarthritis
From: Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis
Structural Feature | Group | ||||
|---|---|---|---|---|---|
AKOA (n = 112) | No AKOA (Reference, n = 242) | Univariate Odds Ratio | |||
n (%) | n (%) | OR (95% CI) | |||
Semi-Quantitative | Degenerative Cruciate Ligaments | Absence | 64 (57%) | 180 (74%) | Reference |
Presence | 48 (43%) | 62 (26%) | 2.18 (1.36, 3.49)* | ||
Degenerative Collateral Ligaments | Absence | 86 (77%) | 206 (85%) | Reference | |
Presence | 26 (23%) | 36 (15%) | 1.73 (0.99, 3.04) | ||
Degenerative Extensor Mechanism | Absence | 62 (55%) | 165 (68%) | Reference | |
Presence | 50 (45%) | 77 (32%) | 1.73 (1.09, 2.74)* | ||
Degenerative Gastrocnemius Tendon | Absence | 63 (56%) | 140 (58%) | Reference | |
Presence | 49 (44%) | 102 (42%) | 1.07 (0.68, 1.68) | ||
Infrapatellar Fat Pad Signal Intensity Alteration | Absence | 53 (47%) | 169 (70%) | Reference | |
Presence | 59 (53%) | 73 (30%) | 2.58 (1.63, 4.09)* | ||
Medial Meniscal Pathology | Absence | 23 (21%) | 115 (48%) | Reference | |
Presence | 89 (79%) | 127 (52%) | 3.50 (2.08, 5.91)* | ||
Lateral Meniscal Pathology | Absence | 63 (56%) | 180 (74%) | Reference | |
Presence | 49 (44%) | 62 (26%) | 2.26 (1.41, 3.62)* | ||
Medial Meniscal Extrusion | Absence | 72 (64%) | 209 (86%) | Reference | |
Presence | 40 (36%) | 33 (14%) | 3.52 (2.07, 6.00)* | ||
Lateral Meniscal Extrusion | Absence | 103 (92%) | 237 (98%) | Reference | |
Presence | 9 (8%) | 5 (2%) | 4.14 (1.36, 12.66) | ||
Quantitative | Effusion-Synovitis Volume^ | Smallest | 46 (41%) | 190 (79%) | Reference |
Largest | 66 (59%) | 52 (21%) | 5.24 (3.23, 8.52)* | ||
Bone Marrow Lesion Volume^ | Smallest | 69 (62%) | 169 (70%) | Reference | |
Largest | 43 (38%) | 73 (30%) | 1.44 (0.90, 2.31) | ||
Cartilage Damage Index^ | Largest | 73 (65%) | 164 (68%) | Reference | |
Smallest | 39 (35%) | 78 (32%) | 1.12 (0.70, 1.80) | ||