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Table 4 Pre-Radiographic Structural Features at 1 Years Prior to Disease Onset Associated with Accelerated Knee Osteoarthritis

From: Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Structural Feature Group
AKOA (n = 112) No AKOA (Reference, n = 242) Univariate Odds Ratio
n (%) n (%) OR (95% CI)
Semi-Quantitative Degenerative Cruciate Ligaments Absence 64 (57%) 180 (74%) Reference
Presence 48 (43%) 62 (26%) 2.18 (1.36, 3.49)*
Degenerative Collateral Ligaments Absence 86 (77%) 206 (85%) Reference
Presence 26 (23%) 36 (15%) 1.73 (0.99, 3.04)
Degenerative Extensor Mechanism Absence 62 (55%) 165 (68%) Reference
Presence 50 (45%) 77 (32%) 1.73 (1.09, 2.74)*
Degenerative Gastrocnemius Tendon Absence 63 (56%) 140 (58%) Reference
Presence 49 (44%) 102 (42%) 1.07 (0.68, 1.68)
Infrapatellar Fat Pad Signal Intensity Alteration Absence 53 (47%) 169 (70%) Reference
Presence 59 (53%) 73 (30%) 2.58 (1.63, 4.09)*
Medial Meniscal Pathology Absence 23 (21%) 115 (48%) Reference
Presence 89 (79%) 127 (52%) 3.50 (2.08, 5.91)*
Lateral Meniscal Pathology Absence 63 (56%) 180 (74%) Reference
Presence 49 (44%) 62 (26%) 2.26 (1.41, 3.62)*
Medial Meniscal Extrusion Absence 72 (64%) 209 (86%) Reference
Presence 40 (36%) 33 (14%) 3.52 (2.07, 6.00)*
Lateral Meniscal Extrusion Absence 103 (92%) 237 (98%) Reference
Presence 9 (8%) 5 (2%) 4.14 (1.36, 12.66)
Quantitative Effusion-Synovitis Volume^ Smallest 46 (41%) 190 (79%) Reference
Largest 66 (59%) 52 (21%) 5.24 (3.23, 8.52)*
Bone Marrow Lesion Volume^ Smallest 69 (62%) 169 (70%) Reference
Largest 43 (38%) 73 (30%) 1.44 (0.90, 2.31)
Cartilage Damage Index^ Largest 73 (65%) 164 (68%) Reference
Smallest 39 (35%) 78 (32%) 1.12 (0.70, 1.80)
  1. *Statistically significant: p < 0.004. ^Comparing the worst tertile (i.e. largest effusion-synovitis/bone marrow lesion, smallest CDI) to the other 2 tertiles