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Table 3 Pre-Radiographic Structural Features at 2 Years Prior to Disease Onset Associated with Accelerated Knee Osteoarthritis

From: Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis

Structural Feature Group
AKOA (n = 90) No AKOA (Reference, n = 158) Univariate Odds Ratio
n (%) n (%) OR (95% CI)
Semi-Quantitative Degenerative Cruciate Ligaments Absence 52 (58%) 120 (76%) Reference
Presence 38 (42%) 38 (24%) 2.31 (1.33, 4.02)*
Degenerative Collateral Ligaments Absence 69 (77%) 140 (89%) Reference
Presence 21 (23%) 18 (11%) 2.37 (1.18, 4.73)*
Degenerative Extensor Mechanism Absence 50 (56%) 111 (70%) Reference
Presence 40 (44%) 47 (30%) 1.89 (1.10, 3.24)*
Degenerative Gastrocnemius Tendon Absence 46 (51%) 95 (60%) Reference
Presence 44 (49%) 63 (40%) 1.44 (0.86, 2.43)
Infrapatellar Fat Pad Signal Intensity Alteration Absence 45 (50%) 112 (71%) Reference
Presence 45 (50%) 46 (29%) 2.44 (1.42, 4.17)*
Medial Meniscal Pathology Absence 26 (29%) 85 (54%) Reference
Presence 64 (71%) 73 (46%) 2.87 (1.65, 4.98)*
Lateral Meniscal Pathology Absence 49 (54%) 121 (77%) Reference
Presence 41 (46%) 37 (23%) 2.74 (1.57, 4.76)*
Medial Meniscal Extrusion Absence 73 (81%) 142 (90%) Reference
Presence 17 (19%) 16 (10%) 2.07 (0.99, 4.33)
Lateral Meniscal Extrusion Absence 87 (97%) 157 (99%) Reference
Presence 3 (3%) 1 (1%) 5.41 (0.56, 52.84)
Quantitative Effusion-Synovitis Volume^ Smallest 46 (51%) 120 (76%) Reference
Largest 44 (49%) 38 (24%) 3.02 (1.74, 5.24)*
Bone Marrow Lesion Volume^ Smallest 62 (69%) 105 (66%) Reference
Largest 28 (31%) 53 (34%) 0.90 (0.51, 1.56)
Cartilage Damage Index^ Largest 62 (69%) 103 (65%) Reference
Smallest 28 (31%) 55 (35%) 0.85 (0.49, 1.47)
  1. *Statistically significant: p < 0.004. ^Comparing the worst tertile (i.e. largest effusion-synovitis /bone marrow lesion, smallest CDI) to the other 2 tertiles