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Table 5 Comparison of preoperative patient demographic between patient prescribed preoperative opioids and opioid-naïve patients

From: Preoperative opioid use is associated with worse patient outcomes after Total joint arthroplasty: a systematic review and meta-analysis

Study Patient Characteristics OU nOU p
Zywiel et al. Mean agea 56 57 0.653
% Malea 31.1 31.1
Mean BMIa 34 34 0.884
Number of patients prescribed antidepressants or anxiolytics 21 10 0.014
Number of patients with chronic back pain or prior back surgery 9 8 0.788
Number of patients actively smoking 10 7 0.419
Number of patients reporting alcohol use 0 1 0.316
Number of patients with systemic corticosteroid use 8 7 0.777
Smith et al. Mean age 67.5 65.2 0.13
% Female 23.7 76.3 0.81
Mean BMI 31.0 31.1 0.84
Mean comorbidities 0.81 0.81 0.91
Preoperative Pain Catastrophizing Scale (SD) 15.3 (10.3) 10.7 (7.7) 0.006
Mean unadjusted preoperative WOMAC Pain (SD) 53.1 (15.7) 57 (12.8) 0.12
Mean unadjusted preoperative WOMAC Function (SD) 51.0 (14.1) 57.9 (13.8) 0.009
Franklin et al. Mean age (SD) 65.3 (11.0) 68.1 (9.7) < 0.001
% Male 28.9 34.1 < 0.001
Mean BMI 32.6 (7.5) 31.7 (6.8) < 0.001
Mean SF-12 PCS (SD) 28.2 (7.1) 30.6 (7.9) < 0.001
Mean SF-12 MCS (SD) 48.7 (12.0) 53.0 (10.8) < 0.001
Pivec et al. Mean agea 55 55
% Malea 54 54
BMIa 30.2 29.9
Number of patients with history of a psychiatric diagnosis 16 7 0.03
Number of patients with history of alcohol abuse 7 6 0.77
Number of patients reporting active smoking 14 12 0.83
Number of patients with history of back pain 11 14 0.24
Number of patients with history of back surgery 7 10 0.60
Number of patients with systemic corticosteroid use 10 6 0.42
Numbers of patients reporting worker’s compensation 2 1 0.56
Nguyen et al. Mean agea 60 58
% Malea 34 34
Mean SF-12 MCS 42.8 49.1
Mean SF-12 PCS 28.8 30.9
Goesling et al. Mean age 59.3 63.6 < 0.001
% Male 43.1 50.1 0.127
BPI Overall Pain Severity (SD) 5.6 (1.8) 4.3 (12.0) < 0.001
HADS Depression (SD) 5.9 (3.5) 4.2 (3.2) < 0.001
HADS Anxiety (SD) 6.2 (3.8) 5.2 (3.6) 0.002
CSQ Catastrophizing (SD) 6.5 (5.8) 4.2 (5.7) 0.001
  1. Abbreviations
  2. SD Standard deviation, WOMAC The Western Ontario and McMaster Universities Osteoarthritis Index, KSS Knee Society Score, HHS Harris Hip Score, OU Patients prescribed preoperative opioids, nOU Preoperative opioid-naïve patients, BPI Brief Pain Inventory, HADS Hospital Anxiety and Depression Scale Depression, CSQ Coping Strategies Questionnaire, ‘-‘not reported in study
  3. Notes
  4. aMatched Cohort