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Table 3 Comparison of scores between patient prescribed preoperative opioids and opioid-naïve patients

From: Preoperative opioid use is associated with worse patient outcomes after Total joint arthroplasty: a systematic review and meta-analysis

Study Patients PRO Statistic Preoperative Score Postoperative Score Mean Changea Differenceb
OU nOU OU nOU OU nOU (OU – nOU)
Zywiel et al. OU (n) = 45 nOU (n) = 45 KSS mean (SD) 38.0 37.0 79.0 (10.0) 92.0 (10.0) 41.0 (14.5) 55.0 (12.0) 14.0
Smith et al. OU (n) = 36 nOU (n) = 120 WOMAC Pain mean (SD) 55.4 56.3 82.9 (12.7) 89.5 (12.7) 27.0 (12.7) 33.6 (12.7) 6.6
Franklin et al. OU (n) = 1544 nOU (n) = 4802 KSS mean (SD) 34.8 37.1 81.3 (15.7) 86.0 (14.1) 46.5 (15.4) 48.9 (14.9) 2.4
Pivec et al. OU (n) = 54 nOU (n) = 54 HHS mean (SD) 43.0 45.0 84.0 (11.5) 91.0 (11.5) 41.0 (81.2) 46.0 (91.1) 5.0
Nguyen et al. OU (n) = 41 nOU (n) = 41 WOMAC mean (SD) 47.5 44.1 65.3 (35.1) 83.1 (35.1) 17.8 (41.8) 39.0 (41.8) 20.2
Goesling et al. OU (n) = 111 nOU (n) = 313 WOMAC mean (SD) 39.3 49.4.0 80.8 (17.3) 85.5 (12.8) 41.5 (16.2) 36.1 (13.8) - 5.4
  1. Abbreviations
  2. PRO Joint or Disease Specific Patient-Reported Outcome Score. All scores Transformed to a 0 to 100-point scale (100 indicating the best possible score), WOMAC The Western Ontario and McMaster Universities Osteoarthritis Index, KSS Knee Society Score, HHS Harris Hip Score, OU Patients prescribed preoperative opioids, nOU Preoperative Opioid-naïve patients, n Number of patients, SD Standard deviations, CI Confidence Interval
  3. Notes
  4. aMean change calculated by the difference in preoperative and postoperative score.
  5. bDifference represents the mean difference between opioid users and non-opioid users with a positive indicating benefit for preoperative opioid-naïve patients.