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Table 7 Summary of studies on imaging for evaluation of treatment

From: Imaging for Dupuytren disease: a systematic review of the literature

Study (year) Design Level of evidence Imaging modality N (hands) Clinical details Outcome parameters Results Additional value MRI Additional value US
Christie (2011) [36] Case-report 5 US 1 (1) A 42-year-old patient undergoing cross-frictional therapy (8 weeks) - Visible changes: US + clinical examination
- ROM
- Symptoms (subjective)
- US: no observed subcutaneous changes
- Clinical examination: decreased nodule size, skin wrinkling and contractile bands
- Increased ROM
- Reduced patient-reported symptoms
No
Yin (2016) [37] Prospective cohort study 3 US 37 (49) Dupuytren patients undergoing injection of triamcinolone acetonide in nodules. Follow-up: 5 years. - Nodule size on US
- Complications
- nodule size: reduction of 40% at 6 months and 56% at 5 years.
- complications: none
Yes
Banks (2017) [38] Retrospective cohort study 4 MRI 6 (8) Patients with superficial fibromatoses of the hand and feet undergoing EBT
Follow-up 4.5 months.
- Nodule volume on MRI
- MRI signal intensity
- Pain (VAS-score)
- Volume: significant decrease from 1.5 to 1.2 cm3
- Signal intensity: significant decrease
- Pain: decrease in VAS-score in patients with high pre-treatment signal intensity
Yes
Strömberg (2017) [39] Prospective cohort study 3 US 39 19 patients undergoing CCH, 20 patients undergoing PNF.
Follow-up 1 year.
- Gap-width measured with US
- Correction of MCP-joint
- Recurrence
- Gap-width (median) 18 mm for both groups
- MCP-correction (median): PNF 46° and CCH 53°
- Recurrence: n = 1
Yes  
Crivello (2015) [40] Prospective cohort study 4 MRI 5 (5) 5 DD patients undergoing CCH in 5 fingers. Follow-up 30 days. - MRI signal intensity
- Cord volume
- MRI signal intensity: significant increase (320%)
- Cord volume: significant decrease (72%)
Yes  
  1. US ultrasound, MRI magnetic resonance imaging, DD Dupuytren disease, PNF percutaneous needle fasciotomy, CCH collagenase clostridium hystoliticum, EBT electron-beam therapy, MCP metacarpophalangeal, ROM range of motion, VAS visual analogue scale