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Table 5 Summary of studies on imaging for measurement of disease activity

From: Imaging for Dupuytren disease: a systematic review of the literature

Author (year) Study type Level of evidence Imaging modality N (hands) Clinical details Outcome measures Results Additional value MRI Additional value US
Ulusoy (2015) [27] Case-report 5 US - (elastography) 1 77-year-old male with bilateral contractures of thumb and little fingers. Echogenicity, vascularity and elasticity. Thickened palmar fascia with high vascularity and mixed echogenicity
Differences in stiffness of DD tissue
Vanek (2018) [28] Prospective cohort study 3 US 38 DD patients undergoing either PNF or CCH-injections. - Nodularity + echogenicity of cords
- 2-year follow-up for signs of residual disease (palpable cord or recurrent contracture)
Palpable cord:
- fibrillar: 1/6, nodular: 14/32
Recurrent contracture:
- fibrillar: 0/6, nodular: 3/32
Yacoe (1993) [26] Prospective case-series. 4 MRI 10 (11) DD patients undergoing fasciectomy - MRI signal intensity
- Cellularity (histology)
- 22 cords and 3 nodules with low or low to intermediate signal intensity and hypo-cellularity
- 10 nodules with intermediate signal and focal areas of high or low signal intensity and high cellularity or mixed composition
  1. US ultrasound, MRI magnetic resonance imaging, DD Dupuytren disease, PNF percutaneous needle fasciotomy, CCH collagenase clostridium hystoliticum
  2. a according to authors