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Table 5 Summary of studies on imaging for measurement of disease activity

From: Imaging for Dupuytren disease: a systematic review of the literature

Author (year)

Study type

Level of evidence

Imaging modality

N (hands)

Clinical details

Outcome measures

Results

Additional value MRI

Additional value US

Ulusoy (2015) [27]

Case-report

5

US - (elastography)

1

77-year-old male with bilateral contractures of thumb and little fingers.

Echogenicity, vascularity and elasticity.

Thickened palmar fascia with high vascularity and mixed echogenicity

Differences in stiffness of DD tissue

–

Yesa

Vanek (2018) [28]

Prospective cohort study

3

US

38

DD patients undergoing either PNF or CCH-injections.

- Nodularity + echogenicity of cords

- 2-year follow-up for signs of residual disease (palpable cord or recurrent contracture)

Palpable cord:

- fibrillar: 1/6, nodular: 14/32

Recurrent contracture:

- fibrillar: 0/6, nodular: 3/32

–

Yes

Yacoe (1993) [26]

Prospective case-series.

4

MRI

10 (11)

DD patients undergoing fasciectomy

- MRI signal intensity

- Cellularity (histology)

- 22 cords and 3 nodules with low or low to intermediate signal intensity and hypo-cellularity

- 10 nodules with intermediate signal and focal areas of high or low signal intensity and high cellularity or mixed composition

Yes

 
  1. US ultrasound, MRI magnetic resonance imaging, DD Dupuytren disease, PNF percutaneous needle fasciotomy, CCH collagenase clostridium hystoliticum
  2. a according to authors