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Table 2 Median biomarker levels in those with clinically defined sciatica and in those with and without MRI findings

From: Inflammatory biomarkers do not distinguish between patients with sciatica and referred leg pain within a primary care population: results from a nested study within the ATLAS cohort

Biomarker Clinically defined sciatica Clinically defined sciatica plus
MRI changesa
  No (n = 26) Yes (n = 93) No (n = 49) Yes (n = 44)
TNFα 11.9 (9.7–13.8) 10.7 (1.0–14.8) 12.39 (1.0–14.74) 9.86 (1.0–14.96)
IL-1β BLD BLD BLD BLD
IL-6 BLD BLD 4.96 (1.6–7.4) 4.21 (0.5–7.7)
IL-33 9.0 (7.2–10.9) 8.0 (6.9–10.4) 9.1(7.9–10.1) 8.8 (7.3–10.1)
IFNγ BLD BLD BLD BLD
TNFRI 5117.1 5087.4 5059.9 5190.3
(4379.9–5692.6) (4525.4–6033.3) (4660.4–5838.9) (4418.2–6113.9)
IL-1RI 1488.8 1469.6 1490.5 1423.9
(1311.8–1620.9) (1273.0–1626.3) (1346.4–1615.8) (1143.8–1654.0)
IL-1RII 6913.9 6985.1 7347.6 6797.3
(5541.3–7819.7) (6099.9–8066.3) (6513.9–8414.0) (5818.4–7825.0)
IL-1Ra 866.3 998.4 974.4 1019.7
(575.8–1267.8) (735.8–1421.6) (693.9–1419.7) (7417.7–1508.9)
CXCL8 2.8 3.6 3.7 4.7
(0.9–3.5) (1.5–6.4) (1.7–6.5) (2.3–7.1)
MCP-1 313.7 257.9 274.3 310.0
(247.7–313.7) (207.8–361.8) (191.1–348.2) (213.6–416.0)
FGFβ BLD BLD BLD BLD
VEGF 42.9 (19.4–62.2) 65.0 (22.0–98.5) 66.2 (27.6–96.9) 63.5 (20.7–123.8)
HGF 265.5 245.9 244.9 245.9
(212.5–351.9) (191.0–321.7) (182.6–315.1) (196.9–315.1)
Ang-2 2164.8 2465.0 2311.2 2870.0
(1637.7–3385.0) (1842.1–3375.4) (1659.9–3070.6) (1921.6–3456.1)
MMP-1 8450.0 7857.2 7344.9 8011.0
(4267.3–13,173.5) (5031.0–15,134.3) (5113.1–12,124.3) (4171.7–24,762.6)
MMP-2 46,778.4 44,214.2 42,714.7 44,418.4
(45,258.0–48,596.9) (37,585.8–50,496.4) (36,594.9–50,419.9) (38,275.4–50,668.8)
MMP-3 13,741.5 12,111.6 12,852.8 11,882.8
(8626.9–22,480.1) (8403.3–18,651.9) (7733.5–18,337.4) (8863.1–18,789.5)
MMP-8 8942.1 7409.5 7842.8 6091.0
(4098.4–11,552.5) (4509.8–12,196.8) (4518.1–10,694.5) (4181.4–13,098.2)
Aggrecan 943.0 922.9 911.2 961.4
(747.4–1302.5) (618.8–1253.4) (624.7–1272.3) (589.5–1243.3)
  1. BLD majority of samples below the limit of detection
  2. aMRI findings of nerve root compression in patients with clinically defined sciatica. (i.e. changes Y/N). Values shown are the median (interquartile range) in pg/ml