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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Expression of minor cartilage collagens and small leucine rich proteoglycans may be relatively reduced in osteoarthritic cartilage

Fig. 5

Ultrastructural evaluation of cartilage collagen. Collagen fibrils in control and OA cartilage tissues were observed by transmission electron microscopy. a and b, Electron photomicrographs of control (a) and OA cartilage (b). Squares indicate the areas for image analysis, which were placed within 10 μm from the periphery of the chondrocytes. Asterisks indicate chondrocytes. C and D, Higher magnification images of the square areas in control (c) and OA cartilage (d). Arrowheads indicate representative collagen fibrils. In a-d, bars indicate 2 μm. e and f, Distribution of collagen fibril diameters in control (e) and OA cartilage (f). g-i, Fibril diameter (g), number of fibrils per μm2 (h), and percentage of the area occupied by fibrils (i) in control (Control) and OA cartilage (OA). Results are the mean + SD. **, P < 0.01 against control

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