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Fig. 1 | BMC Musculoskeletal Disorders

Fig. 1

From: Expression of minor cartilage collagens and small leucine rich proteoglycans may be relatively reduced in osteoarthritic cartilage

Fig. 1

Expression of cartilage procollagen genes in OA (OA) and control cartilage (Control). Cartilage samples were obtained from control or OA knees and precisely divided into superficial, middle and deep cartilage zones using LCM. In each zone, expression of respective procollagen genes was determined by qPCR using GAPDH as a housekeeping gene. Since OA cartilage samples were obtained from preserved areas and degenerated areas with various degrees of cartilage degeneration, results are shown for the preserved areas (Preserved), slightly degenerated areas (Slight), moderately degenerated areas (Mod) and severely degenerated areas (Severe). The results of type II (a), type IX (b-d) and type XI procollagen genes (e and f) are shown. In each graph, open, shaded and solid bars indicate the findings for the superficial, middle and deep cartilage zones, respectively. Bars are the mean + SD of 11–34 samples. *, p < 0.05 and **, p < 0.01 versus the corresponding zone in control cartilage

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