Minimal clinically important decline in physical function over one year: EPOSA study

Table 1 Baseline characteristics and change in physical function and in the anchors after 12–18 months

	Baseline			Change: 12–18 months follow-up - baseline			P
Age, n, mean (SD), median (IQR), y	1886	73.8 ± 5.0	73 (70.77)
Female Sex, n (%)	1886	977 (51.8)
High education, n (%)	1886	1120 (58.8)
Country, n (%)	1886
Italy		312 (16.8)
The Netherlands		407 (22.0)
Spain		413 (22.4)
Sweden		392 (23.0)
UK		362 (15.8)
Clinical hand OA, n (%)	1886	1842 (16.7)
Clinical hip/knee OA, n (%)	1886	1845 (22.6)
AUSCAN for hand OA^a, n, mean ± SD, median (IQR)
Physical function	1842	9.1 ± 15.4	0 (0,11)	1842	1.1 ± 11.3	0 (0,4)	<.0001
Pain^c	1842	7.6 ± 15.2	0 (0,5)	1842	1.7 ± 14.4	0 (0,0)	0.1949
Stiffness	1842	10.0 ± 18.7	0 (0,25)	1842	1.0 ± 17.2	0 (0,0)	0.1358
WOMAC for hip/knee OA^a, n, mean ± SD, median (IQR)
Physical function	1845	8.5 ± 13.2	2 (0,12)	1845	1.5 ± 11.3	0 (−1,4)	0.0123
Pain	1845	10.0 ± 14.3	5 (0,15)	1845	1.4 ± 13.2	0 (−5,5)	0.2579
Stiffness	1845	12.9 ± 18.6	0 (0,25)	1845	0.3 ± 17.9	0 (0,12)	0.0390
Grip strength^b, n, mean ± SD, median (IQR), kg	1862	27.7 ± 10.2	26 (20,35)	1826	−1.1 ± 5.8	−1 (−3.5,1.5)	0.0004
Walking-test time^c, n, mean ± SD, median (IQR), sec	1854	3.3 ± 1.6	3 (2.3,3.8)	1830	0.1 ± 1.6	0 (−0.5,0.6)	<.0001
HADS anxiety^d, n, mean ± SD, median (IQR)	1886	4.5 ± 3.5	4 (2,7)	1872	−0.6 ± 2.6	−1 (−2,1)	<.0001
HADS depression^d, n, mean ± SD, median (IQR)	1886	3.5 ± 3.0	3 (1,5)	1875	−0.3 ± 2.4	0 (−1,1)	<.0001
EQ-5D-5 L^e, n, mean ± SD, median (IQR)	1876	0.8 ± 0.2	0.8 (0.7,1.0)	1855	0.0 ± 0.2	0 (0.0,0.1)	0.0059
EQ VAS^f, n, mean ± SD, median (IQR)	1882	76.5 ± 16.2	80 (70,90)	1875	−0.5 ± 15.6	0 (−10,5)	0.0114

Weighted data. Numbers of subjects, age, and sex were unweighted data. Except where indicated otherwise, values are the percent of subjects
EPOSA European Project on OSteoArthritis, SD Standard deviation, IQR interquartile range, AUSCAN AUStralian/CANadian Osteoarthritis Hand Index, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, OA osteoarthritis, HADS Hospital Anxiety and Depression Scales, EQ-5D-5 L Health status using five dimensions, EQ VAS Health status using the visual analogue scale
^a Possible scores range from 0 to 100, with 100 indicating worse health status. ^b Lower values indicate worse performance. ^c Higher values indicate worse performance. ^d Possible scores range from 0 to 21, a score ≥ 8 indicates anxiety and/or depression. ^e Possible scores range from − 0.594 to 1, lower values indicating worse health status. ^f Possible scores range from 0 to 100, with 0 indicating worse health status
The P are bold where they are less than or equal to the significance level cut-off of 0.05

ISSN: 1471-2474