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Table 1 Cases of lower leg osteomyelitis caused by Actinomycosis reported in English language literature between 1990 and 2017 with our patient

From: Actinomycotic osteomyelitis of a long bone in an immunocompetent adult: a case report and literature review

Cases Age/Gender Location Underlying disease Culture result Pathologic exam Treatment Outcome
Atwaru et al. [9] 32/M Calcaneus None Primary: none
Delayed: Actinomyces Israelii
Primary: none
Delayed: Actinomyces
Antituberculosis medication → Penicillin (PO) 6 W Total calcanectomy
Lee et al. [15] 59/M Fibular None Actinomyces meyeri
Fusobacterium nucleatum
Actinomyces Fibular excision
Ampicillin-sulbactam (IV) 3 W + Amoxicillin-clavulanate (PO) 8 W
Fibular excision
Apotheloz et al. [5] 47/M Rt. lung
Rt. Proximal tibia
Alcoholics
smoking
Actinomyces meyeri Actinomyces Synovectomy
Penicillin (IV) 8 W + penicillin (PO) 12 M
Cured
Tekin et al. [20] 90/F Knee, ankle joint
(proximal & distal tibia)
Unknown Unknown Actinomyces Ampicillin/sulbactam (IV) 2 W +
Amoxicillin-clavulanate (PO) 6 M
Lower leg amputation
Kundu et al. [6] 50/M Knee joint
(distal femur + proximal tibia)
Unknown Actinomyces Actinomyces Repeated bone curettage
Penicillin (IV) 6 W
Failed- amputation
Nayak et.al. [17] 30/M Calcaneus Unknown Actinomyces
MSSA
Actinomyces Debridement/Antibead insertion
ketaconazole + Tetracycline + Septran-DS (PO)6 W
Cured
Yusof et al. [7] 34/M Knee joint, proximal tibia Unknown None Actinomyces Bactrim and amoxycillin (PO) 6 M Cured,
But ROM limitation
Nandy et al. [21] 52/M Talus, medial malleolus None Unknown Actinomyces Clindamycin (IV) 3 W Below knee amputation
Our patient 52/F Distal femur None None Actinomyces Repeated bone curettage
Penicillin (IV)8 W+ Amoxicillin-clavulanate (PO) 6 W
Cured