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Table 2 Results of baseline analyses for primary and exploratory outcome parameters between groups

From: Is treated HIV infection associated with knee cartilage degeneration and structural changes? A longitudinal study using data from the osteoarthritis initiative

Parameters Control group (n = 20) HIV group (n = 10) Effect size
(95% CI)b
P value
Adjusted meansa Adjusted meansa
Primary outcome parameters
 Regular T2 values
  Global knee T2 32.71 ± 0.43 32.90 ± 0.60 0.19 (−1.35, 1.73) 0.801
 Laminar T2 values
  Global bone layer T2 29.92 ± 0.37 30.14 ± 0.52 0.22 (− 1.10, 1.54) 0.737
  Global articular layer T2 34.85 ± 0.50 36.03 ± 0.71 1.17 (−0.62, 2.97) 0.188
 Texture parameters
  Global knee contrast 304.98 ± 16.45 307.59 ± 23.27 2.61 (− 56.39, 61.61) 0.928
  Global knee variance 223.60 ± 11.76 224.22 ± 16.64 0.61 (−41.57, 42.79) 0.976
  Global knee entropy 6.29 ± 0.04 6.40 ± 0.05 0.11 (− 0.03, 0.25) 0.124
Exploratory outcome parameters
 WORMS scores
  Cartilage sum score 4.15 ± 0.49 3.15 ± 0.69 −1.00 (− 2.65, 0.66) 0.238
  Meniscus sum score 2.58 ± 0.44 1.68 ± 0.62 −0.90 (− 2.40, 0.60) 0.241
  BMEPs sum score 2.60 ± 0.38 1.86 ± 0.53 −0.74 (− 2.02, 0.54) 0.260
  Subchondral cysts sum score 2.15 ± 0.30 0.65 ± 0.42 −1.51 (−2.51, −0.50) 0.003
  Effusion score 0.05 ± 0.04 0.25 ± 0.06 0.20 (0.05, 0.35) 0.009
  Ligament sum score 0.45 ± 0.15 0.31 ± 0.21 −0.14 (−0.66, 0.37) 0.590
 IPFP and SPFP signal abnormalities
  IPFP signal abnormalities (size) 0.78 ± 0.13 1.39 ± 0.19 0.62 (0.16, 1.07) 0.008
  IPFP signal abnormalities (SI) 1.30 ± 0.17 1.55 ± 0.24 0.24 (−0.34, 0.83) 0.409
  SPFP signal abnormalities (SI) 1.35 ± 0.11 1.80 ± 0.16 0.45 (0.09, 0.81) 0.015
  1. a adjusted means were expressed as mean ± SD. b effect size for difference in each parameter between groups, with (95% confidence intervals, CI) provided. Adjusted means and effect size were corrected for age, sex, race and baseline BMI and K&L grades. P values < 0.05 were in bold, indicating significant difference between two groups in corresponding score. BMEP bone marrow edema pattern, IPFP infrapatellar fat pad, SPFP suprapatellar fat pad, SI signal intensity