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Table 2 Results of baseline analyses for primary and exploratory outcome parameters between groups

From: Is treated HIV infection associated with knee cartilage degeneration and structural changes? A longitudinal study using data from the osteoarthritis initiative

Parameters

Control group (n = 20)

HIV group (n = 10)

Effect size

(95% CI)b

P value

Adjusted meansa

Adjusted meansa

Primary outcome parameters

 Regular T2 values

  Global knee T2

32.71 ± 0.43

32.90 ± 0.60

0.19 (−1.35, 1.73)

0.801

 Laminar T2 values

  Global bone layer T2

29.92 ± 0.37

30.14 ± 0.52

0.22 (− 1.10, 1.54)

0.737

  Global articular layer T2

34.85 ± 0.50

36.03 ± 0.71

1.17 (−0.62, 2.97)

0.188

 Texture parameters

  Global knee contrast

304.98 ± 16.45

307.59 ± 23.27

2.61 (− 56.39, 61.61)

0.928

  Global knee variance

223.60 ± 11.76

224.22 ± 16.64

0.61 (−41.57, 42.79)

0.976

  Global knee entropy

6.29 ± 0.04

6.40 ± 0.05

0.11 (− 0.03, 0.25)

0.124

Exploratory outcome parameters

 WORMS scores

  Cartilage sum score

4.15 ± 0.49

3.15 ± 0.69

−1.00 (− 2.65, 0.66)

0.238

  Meniscus sum score

2.58 ± 0.44

1.68 ± 0.62

−0.90 (− 2.40, 0.60)

0.241

  BMEPs sum score

2.60 ± 0.38

1.86 ± 0.53

−0.74 (− 2.02, 0.54)

0.260

  Subchondral cysts sum score

2.15 ± 0.30

0.65 ± 0.42

−1.51 (−2.51, −0.50)

0.003

  Effusion score

0.05 ± 0.04

0.25 ± 0.06

0.20 (0.05, 0.35)

0.009

  Ligament sum score

0.45 ± 0.15

0.31 ± 0.21

−0.14 (−0.66, 0.37)

0.590

 IPFP and SPFP signal abnormalities

  IPFP signal abnormalities (size)

0.78 ± 0.13

1.39 ± 0.19

0.62 (0.16, 1.07)

0.008

  IPFP signal abnormalities (SI)

1.30 ± 0.17

1.55 ± 0.24

0.24 (−0.34, 0.83)

0.409

  SPFP signal abnormalities (SI)

1.35 ± 0.11

1.80 ± 0.16

0.45 (0.09, 0.81)

0.015

  1. a adjusted means were expressed as mean ± SD. b effect size for difference in each parameter between groups, with (95% confidence intervals, CI) provided. Adjusted means and effect size were corrected for age, sex, race and baseline BMI and K&L grades. P values < 0.05 were in bold, indicating significant difference between two groups in corresponding score. BMEP bone marrow edema pattern, IPFP infrapatellar fat pad, SPFP suprapatellar fat pad, SI signal intensity