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Table 2 Percentage responders at 52 weeks follow-up (n = 156)

From: The effectiveness of high molecular weight hyaluronic acid for knee osteoarthritis in patients in the working age: a randomised controlled trial

  intervention (n = 77) control (n = 79) NNT OR (95% CI) p
all subjects analysed
 responder set 1a 57.1% 34.2% 4.4 2.6 (1.3; 4.9) 0.006
 responder set 2b 54.5% 34.2% 4.9 2.3 (1.2; 4.4) 0.015
1st additional analysisc
 responder set 1a 50.6% 31.6% 5.3 2.2 (1.2; 4.3) 0.022
 responder set 2b 48.1% 32.9% 6.6 1.9 (1.0; 3.6) 0.072
2nd additional analysisd
 responder set 1a 50.6% 31.6% 5.3 2.2 (1.2; 4.3) 0.022
 responder set 2b 48.1% 31.6% 6.1 2.0 (1.0; 3.8) 0.049
  1. apain during rest included in responder domains next to function and PGA, bpain during activity included in responder domains next to function and PGA, csubjects receiving major knee related surgery considered non-responder, dSubjects receiving any knee related surgery considered non-responder, OR: Odds ratio, CI: confidence interval, NNT: number needed to treat