The effectiveness of high molecular weight hyaluronic acid for knee osteoarthritis in patients in the working age: a randomised controlled trial

Table 2 Percentage responders at 52 weeks follow-up (n = 156)

	intervention (n = 77)	control (n = 79)	NNT	OR (95% CI)	p
all subjects analysed
responder set 1^a	57.1%	34.2%	4.4	2.6 (1.3; 4.9)	0.006
responder set 2^b	54.5%	34.2%	4.9	2.3 (1.2; 4.4)	0.015
1st additional analysis^c
responder set 1^a	50.6%	31.6%	5.3	2.2 (1.2; 4.3)	0.022
responder set 2^b	48.1%	32.9%	6.6	1.9 (1.0; 3.6)	0.072
2nd additional analysis^d
responder set 1^a	50.6%	31.6%	5.3	2.2 (1.2; 4.3)	0.022
responder set 2^b	48.1%	31.6%	6.1	2.0 (1.0; 3.8)	0.049

^apain during rest included in responder domains next to function and PGA, ^bpain during activity included in responder domains next to function and PGA, ^csubjects receiving major knee related surgery considered non-responder, ^dSubjects receiving any knee related surgery considered non-responder, OR: Odds ratio, CI: confidence interval, NNT: number needed to treat

ISSN: 1471-2474