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Table 2 Demographics by age at enrollment

From: Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry

Characteristic Children (age < 18 y) (n = 121) Adults (age ≥ 18 y) (n = 148) Total (N = 269)
Age at enrollment,a y n = 121 n = 148 n = 269
 Mean (SD) 5.7 (4.7) 48.8 (15.4) 29.4 (24.5)
 Median (min, max) 4.3 (−0.01, 17.3) 51.4 (18.5, 78.9) 26.0 (−0.01, 78.9)
Sex, n (%) n = 121 n = 148 n = 269
 Female 74 (61.2) 108 (73.0) 182 (67.7)
Race,b n (%) n = 111 n = 140 n = 251
 White 64 (57.7) 126 (90.0) 190 (75.7)
 Asian 35 (31.5) 3 (2.1) 38 (15.1)
 American Indian or Alaska Native 0 2 (1.4) 2 (0.8)
 Native Hawaiian or other Pacific Islander 0 1 (0.7) 1 (0.4)
 Other/multiple 5 (4.5) 4 (2.9) 9 (3.6)
 Not reported 7 (6.3) 4 (2.9) 11 (4.4)
Ethnicity,b n (%) n = 121 n = 147 n = 268
 Not Hispanic or Latino 103 (85.1) 116 (78.9) 219 (81.7)
 Hispanic or Latino 4 (3.3) 18 (12.2) 22 (8.2)
 Not reported 14 (11.6) 13 (8.8) 27 (10.1)
Family history of HPP, n (%) n = 117 n = 135 n = 252
 Yes 50 (42.7) 66 (48.9) 116 (46.0)
 No 61 (52.1) 54 (40.0) 115 (45.6)
 Not reported 6 (5.1) 15 (11.1) 21 (8.3)
Treated with asfotase alfa at enrollment, n (%) n = 121 n = 148 n = 269
 Yes 45 (37.2) 26 (17.6) 71 (26.4)
  1. HPP hypophosphatasia, SD standard deviation
  2. aNegative values for age indicate enrollment date occurred during pregnancy
  3. bThe race and ethnicity categories used are those recommended by the US National Institutes of Health