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Table 2 Demographics by age at enrollment

From: Diagnostic delay is common among patients with hypophosphatasia: initial findings from a longitudinal, prospective, global registry

Characteristic

Children (age < 18 y) (n = 121)

Adults (age ≥ 18 y) (n = 148)

Total (N = 269)

Age at enrollment,a y

n = 121

n = 148

n = 269

 Mean (SD)

5.7 (4.7)

48.8 (15.4)

29.4 (24.5)

 Median (min, max)

4.3 (−0.01, 17.3)

51.4 (18.5, 78.9)

26.0 (−0.01, 78.9)

Sex, n (%)

n = 121

n = 148

n = 269

 Female

74 (61.2)

108 (73.0)

182 (67.7)

Race,b n (%)

n = 111

n = 140

n = 251

 White

64 (57.7)

126 (90.0)

190 (75.7)

 Asian

35 (31.5)

3 (2.1)

38 (15.1)

 American Indian or Alaska Native

0

2 (1.4)

2 (0.8)

 Native Hawaiian or other Pacific Islander

0

1 (0.7)

1 (0.4)

 Other/multiple

5 (4.5)

4 (2.9)

9 (3.6)

 Not reported

7 (6.3)

4 (2.9)

11 (4.4)

Ethnicity,b n (%)

n = 121

n = 147

n = 268

 Not Hispanic or Latino

103 (85.1)

116 (78.9)

219 (81.7)

 Hispanic or Latino

4 (3.3)

18 (12.2)

22 (8.2)

 Not reported

14 (11.6)

13 (8.8)

27 (10.1)

Family history of HPP, n (%)

n = 117

n = 135

n = 252

 Yes

50 (42.7)

66 (48.9)

116 (46.0)

 No

61 (52.1)

54 (40.0)

115 (45.6)

 Not reported

6 (5.1)

15 (11.1)

21 (8.3)

Treated with asfotase alfa at enrollment, n (%)

n = 121

n = 148

n = 269

 Yes

45 (37.2)

26 (17.6)

71 (26.4)

  1. HPP hypophosphatasia, SD standard deviation
  2. aNegative values for age indicate enrollment date occurred during pregnancy
  3. bThe race and ethnicity categories used are those recommended by the US National Institutes of Health