Marine omega-3 polyunsaturated fatty acid intakea | |||||
---|---|---|---|---|---|
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | |
HR (95%CI) | HR (95%CI) | HR (95%CI) | HR (95%CI) | ||
All RA | |||||
Cases/person-years | 251/945,683 | 269/969,619 | 279/980,365 | 281/968,243 | |
Age-adjusted modelb | 1.00 (Ref) | 1.03 (0.87–1.22) | 1.05 (0.88–1.24) | 1.04 (0.88–1.24) | 0.65 |
Multivariable modelc | 1.00 (Ref) | 1.05 (0.88–1.25) | 1.09 (0.91–1.31) | 1.12 (0.91–1.37) | 0.28 |
Seropositive RA | |||||
Cases/person-years | 167/943,993 | 153/967,552 | 177/978,198 | 175/966,331 | |
Age-adjusted modelb | 1.00 (Ref) | 0.88 (0.70–1.09) | 1.00 (0.81–1.23) | 0.97 (0.79–1.21) | 0.82 |
Multivariable modelc | 1.00 (Ref) | 0.92 (0.73–1.15) | 1.08 (0.86–1.36) | 1.12 (0.87–1.43) | 0.19 |
Seronegative RA | |||||
Cases/person-years | 84/943,360 | 116/967,367 | 102/977,670 | 106/965,464 | |
Age-adjusted modelb | 1.00 (Ref) | 1.34 (1.01–1.77) | 1.14 (0.86–1.53) | 1.18 (0.89–1.58) | 0.64 |
Multivariable modelc | 1.00 (Ref) | 1.31 (0.98–1.75) | 1.12 (0.82–1.51) | 1.14 (0.81–1.59) | 0.92 |
All RA among ≤ 55 years | |||||
Cases/person-years | 125/565,147 | 139/564,890 | 120/548,635 | 107/513,366 | |
Age-adjusted modelb | 1.00 (Ref) | 1.10 (0.87–1.41) | 0.96 (0.75–1.24) | 0.90 (0.69–1.17) | 0.23 |
Multivariable modelc | 1.00 (Ref) | 1.10 (0.86–1.41) | 0.98 (0.75–1.27) | 0.93 (0.69–1.25) | 0.40 |
All RA among > 55 years | |||||
Cases/person-years | 126/386,863 | 130/411,627 | 159/438,231 | 174/461,250 | |
Age-adjusted modelb | 1.00 (Ref) | 0.96 (0.75–1.23) | 1.12 (0.89–1.42) | 1.16 (0.92–1.47) | 0.097 |
Multivariable modelc | 1.00 (Ref) | 1.00 (0.77–1.28) | 1.20 (0.93–1.54) | 1.29 (0.98–1.69) | 0.031 |