Table 3 Hazard ratios for rheumatoid arthritis phenotypes according to categories of cumulative average total fish intake in the Nurses’ Health Study and Nurses’ Health Study II (n = 166,013)

 Cases/person-years

53/185,861

175/705,447

513/1,888,251

200/649,928

139/434,424

 Age-adjusted model^a

1.00 (Ref)

0.82 (0.60–1.11)

0.83 (0.62–1.11)

0.87 (0.64–1.19)

0.92 (0.66–1.27)

0.48

 Multivariable model^b

1.00 (Ref)

0.82 (0.60–1.12)

0.84 (0.63–1.12)

0.89 (0.65–1.22)

0.93 (0.67–1.28)

0.42

 Cases/person-years

34/185,640

116/704,320

308/1,884,304

133/648,527

81/433,284

 Age-adjusted model^a

1.00 (Ref)

0.86 (0.59–1.27)

0.80 (0.56–1.15)

0.95 (0.64–1.39)

0.87 (0.57–1.31)

0.72

 Multivariable model^b

1.00 (Ref)

0.86 (0.59–1.27)

0.82 (0.57–1.17)

0.97 (0.66–1.43)

0.88 (0.58–1.33)

0.66

 Cases/person-years

19/185,340

59/703,876

205/1,883,542

67/648,136

58/432,966

 Age-adjusted model^a

1.00 (Ref)

0.74 (0.44–1.25)

0.88 (0.54–1.41)

0.76 (0.45–1.27)

0.99 (0.59–1.69)

0.48

 Multivariable model^b

1.00 (Ref)

0.74 (0.44–1.25)

0.88 (0.55–1.42)

0.77 (0.46–1.29)

1.01 (0.59–1.71)

0.45

 Cases/person-years

37/134,613

113/458,908

213/1,072,596

74/301,548

54/224,372

 Age-adjusted model^a

1.00 (Ref)

0.85 (0.59–1.24)

0.64 (0.45–0.91)

0.72 (0.48–1.08)

0.71 (0.46–1.10)

0.25

 Multivariable model^b

1.00 (Ref)

0.86 (0.59–1.25)

0.66 (0.46–0.94)

0.75 (0.50–1.12)

0.72 (0.47–1.11)

0.29

 Cases/person-years

16/52,659

62/252,365

300/828,551

126/352,538

85/211,857

 Age-adjusted model^a

1.00 (Ref)

0.82 (0.47–1.42)

1.19 (0.72–1.98)

1.19 (0.70–2.01)

1.30 (0.75–2.23)

0.043

 Multivariable model^b

1.00 (Ref)

0.82 (0.47–1.42)

1.21 (0.73–2.00)

1.21 (0.71–2.05)

1.32 (0.76–2.27)

0.037