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Table 2 Differential gene expression between the tissue adjacent to the impact site (ADJ) and the area of impact (AOI) at each time point for each type of impact (axial and shear)

From: Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads

Gene Fold Changes Fold Changes
Axial ADJ vs. AOI Shear ADJ vs. AOI
Day 0 Day 3 Day 7 Day 14 Day 0 Day 3 Day 7 Day 14
Cartilage Matrix
Col1a1 13.50 2.36 1.53 0.22 10.03 0.40 0.93 0.54
Col2a1 0.78 1.42 0.81 1.03 0.57 0.57 0.37 0.78
Acan 1.06 1.26 0.96 0.73 1.03 0.78 0.70 1.04
Sox9 0.62 0.49 0.82 1.31 0.50 0.96 1.04 0.39
Opn 2.89 1.19 1.06 2.75 2.99 0.87 0.66 1.46
Comp 0.87 0.69 0.90 1.07 1.48 0.71 0.90 0.97
Degradative Enzymes & Inhibitors
Mmp1 0.55 1.26 0.49 1.05 0.64 1.10 1.37 3.38
Mmp3 0.52 2.23 0.70 1.90 0.89 1.60 0.16 4.90
Mmp13 0.96 1.12 0.88 0.81 1.67 0.42 1.20 2.70
Timp1 1.45 0.85 0.77 0.87 0.92 0.74 0.95 1.41
Timp2 2.44 2.73 0.91 1.76 0.78 0.94 0.97 1.31
Adamts5 1.84 1.81 0.94 0.86 2.17 1.07 0.81 5.24
Inflammatory Response & Signaling
Ihh 1.04 3.53 1.85 0.74 0.39 1.69 0.41 0.34
Tgfb 1.27 0.98 1.24 1.46 1.54 1.20 0.76 1.10
Inos 0.36 0.87 1.39 1.18 1.11 1.15 1.54 1.35
Chi3l1 1.00 0.93 0.96 0.75 0.51 0.63 1.14 0.79
Cell Proliferation & Apoptosis
Casp8 0.63 0.56 0.84 1.34 0.50 1.01 1.05 0.39
Fas 0.37 1.36 1.70 1.24 1.95 1.24 0.58 1.49
  1. Significant q-values (q < .2) are indicated by bold type