Skip to main content

Table 2 Differential gene expression between the tissue adjacent to the impact site (ADJ) and the area of impact (AOI) at each time point for each type of impact (axial and shear)

From: Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads

Gene

Fold Changes

Fold Changes

Axial ADJ vs. AOI

Shear ADJ vs. AOI

Day 0

Day 3

Day 7

Day 14

Day 0

Day 3

Day 7

Day 14

Cartilage Matrix

Col1a1

13.50

2.36

1.53

0.22

10.03

0.40

0.93

0.54

Col2a1

0.78

1.42

0.81

1.03

0.57

0.57

0.37

0.78

Acan

1.06

1.26

0.96

0.73

1.03

0.78

0.70

1.04

Sox9

0.62

0.49

0.82

1.31

0.50

0.96

1.04

0.39

Opn

2.89

1.19

1.06

2.75

2.99

0.87

0.66

1.46

Comp

0.87

0.69

0.90

1.07

1.48

0.71

0.90

0.97

Degradative Enzymes & Inhibitors

Mmp1

0.55

1.26

0.49

1.05

0.64

1.10

1.37

3.38

Mmp3

0.52

2.23

0.70

1.90

0.89

1.60

0.16

4.90

Mmp13

0.96

1.12

0.88

0.81

1.67

0.42

1.20

2.70

Timp1

1.45

0.85

0.77

0.87

0.92

0.74

0.95

1.41

Timp2

2.44

2.73

0.91

1.76

0.78

0.94

0.97

1.31

Adamts5

1.84

1.81

0.94

0.86

2.17

1.07

0.81

5.24

Inflammatory Response & Signaling

Ihh

1.04

3.53

1.85

0.74

0.39

1.69

0.41

0.34

Tgfb

1.27

0.98

1.24

1.46

1.54

1.20

0.76

1.10

Inos

0.36

0.87

1.39

1.18

1.11

1.15

1.54

1.35

Chi3l1

1.00

0.93

0.96

0.75

0.51

0.63

1.14

0.79

Cell Proliferation & Apoptosis

Casp8

0.63

0.56

0.84

1.34

0.50

1.01

1.05

0.39

Fas

0.37

1.36

1.70

1.24

1.95

1.24

0.58

1.49

  1. Significant q-values (q < .2) are indicated by bold type