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Table 5 Adiponectin at 18 and 22 years old and BMD at 22 years, males

From: Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

 

BMD - 22 years (mg/cm2)

Total body

β (95% CI)

Lumbar spine

β (95% CI)

Femur neck

β (95% CI)

Crude

Adjusted

Crude

Adjusted

Crude

Adjusted

18 years

      

 Adiponectin (μg/mL - tertiles)

p = 0.005

p = 0.166

p = 0.186

p = 0.244

p = 0.089

p = 0.315

  1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

  2

−0.7 (−48.0; 46.5)

−6.4 (−58.6; 45.8)

30.5 (−33.0; 94.1)

23.5 (−16.3; 108.4)

20.5 (− 61.4; 102.4)

−22.3 (− 121.8; 77.2)

  3

− 69.2 (−116.1; − 22.4)

−39.5 (−93.8; 14.9)

−44.5 (− 107.1; 18.1)

−58.8 (− 146.2; 28.6)

−72.4 (− 153.1; 8.2)

−51.6 (− 154.1; 50.0)

22 years

      

 Adiponectin (μg/mL - tertiles)

p < 0.001

p < 0.001

p = 0.001

p = 0.030

p < 0.001

p = 0.006

  1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

  2

−24.3 (−36.4; −12.1)

−7.5 (−19.4; 4.4)

−15.3 (− 33.1; 2.5)

−4.6 (− 24.3; 15.1)

−28.6 (− 49.3; − 7.9)

−4.0 (− 26.0; 18.1)

  3

− 40.3 (− 52.5; − 28.1)

− 23.3 (− 35.5; − 11.1)

− 31.1 (− 49.0; − 13.3)

− 22.5 (− 42.9; − 2.2)

− 55.2 (− 75.9; − 34.5)

− 31.8 (− 55.5; − 9.1)

18 and 22 yearsa

      

 Adiponectin in the highest tertile

p = 0.015

p = 0.371

p = 0.279

p = 0.384

p = 0.148

p = 0.825

 None

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Only at 18

− 65.8 (− 126.3; − 5.3)

− 47.0 (− 120.6; 26.5)

− 55.1 (− 138.5; 28.3)

−80.7 (− 200.8; 39.4)

− 41.2 (− 146.1; 63.7)

−28.4 (− 169.3; 112.5)

 Only at 22

− 28.2 (− 95.8; 39.3)

− 39.6 (− 119.8; 40.5)

−6.1 (− 99.3; 87.1)

− 29.7 (− 160.8; 101.3)

− 7.4 (− 124.6; 109.9)

− 8.4 (− 162.2; 145.3)

 Both 18 and 22 years

− 71.8 (− 120.9; − 22.6)

−37.4 (− 95.9; 21.1)

− 56.7 (− 123.4; 9.9)

− 65.9 (− 161.1; 29.3)

−96.8 (− 180.6; − 13.0)

−51.6 (− 163.3; 60.1)

  1. Total males sample 18 years n = 138 / 22 years n = 1568
  2. BMD bone mineral density
  3. Adjusted for birth weight, maternal smoking during pregnancy, gestational age, skin color, schooling (years - 18y), asset index (quintiles - 22y), smoking status (18 and 22y), alcohol use (AUDIT - 18 and 22y), physical activity (minutes per week 18 and 22y), medical diagnosis of asthma, diabetes and hypertension (22y), BMI (continuous - 22y), height (22y), daily calcium intake (18y and 22y), any kind of corticoids use in the last three months (22y), insulin (22y) and testosterone (22y)
  4. P-values by Wald’s test for linear tendency, except aWald’s test for heterogeneity