Table 4 CRP and Il-6 at 18 and 22 years old and BMD at 22 years, females
BMD - 22 years (mg/cm2) | ||||||
|---|---|---|---|---|---|---|
Total body β (95% CI) | Lumbar spine β (95% CI) | Femur neck β (95% CI) | ||||
Crude | Adjusted | Crude | Adjusted | Crude | Adjusted | |
18 years | ||||||
CRP (log mg/L - tertiles) | p < 0.001 | p = 0.265 | p < 0.001 | p = 0.359 | p < 0.001 | p = 0.953 |
1 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
2 | 18.7 (9.09; 28.3) | 2.4 (−7.6; 11.2) | 28.3 (12.8; 43.9) | 9.8 (− 7.2; 26.7) | 15.7 (0.1; 31.3) | −6.2 (−22.4; 9.9) |
3 | 33.4 (23.8; 43.0) | 5.8 (−4.4; 16.0) | 40.1 (24.4; 55.7) | 8.5 (−9.8; 26.8) | 37.1 (21.4; 52.8) | 0.5 (−17.0; 18.0) |
IL-6 (log pg/mL - tertiles) | p < 0.001 | p = 0.506 | p < 0.001 | p = 0.217 | p < 0.001 | p = 0.730 |
1 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
2 | 14.5 (4.7; 24.4) | 2.2 (−6.8; 11.2) | 27.7 (11.8; 43.7) | 14.6 (−1.6; 30.8) | 16.2 (0.2; 32.1) | 1.2 (−14.2; 16.7) |
3 | 28.3 (18.5; 38.2) | 3.2 (−6.3; 12.7) | 40.7 (24.7; 56.6) | 10.3 (−6.7; 27.4) | 39.4 (23.4; 55.3) | 2.9 (−13.4; 19.1) |
CRP and IL-6 in the highest tertile | p < 0.001 | p = 0.353 | p < 0.001 | p = 0.651 | p < 0.001 | p = 0.588 |
None | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Only CRP or IL-6 | 11.7 (2.8; 20.9) | 0.7 (−7.9; 9.3) | 13.0 (−1.8; 27.7) | −2.1 (− 17.5; 13.3) | 15.8 (1.0; 30.5) | 1.5 (− 13.2; 16.2) |
Both CRP and IL-6 | 38.6 (27.4; 49.9) | 5.9 (− 5.2; 16.9) | 45.3 (27.1; 63.6) | 6.5 (− 13.4; 26.3) | 52.3 (34.1; 70.5) | 5.4 (− 13.5; 24.5) |
22 years | ||||||
CRP (log mg/L - tertiles) | p < 0.001 | p = 0.004 | p < 0.001 | p = 0.330 | p < 0.001 | p = 0.630 |
1 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
2 | 18.6 (9.1; 28.1) | −3.3 (−12.6; 5.9) | 25.0 (9.6; 40.4) | 2.8 (−13.8; 19.4) | 22.0 (6.6; 37.3) | −2.1 (− 17.9; 13.7) |
3 | 24.9 (15.1; 34.6) | −15.2 (− 25.4; −4.9) | 28.5 (12.7; 44.2) | −9.0 (− 27.4; 9.4) | 35.5 (19.8; 51.2) | − 4.3 (− 21.9; 13.3) |
IL-6 (log pg/mL - tertiles) | p < 0.001 | p = 0.133 | p < 0.001 | p = 0.813 | p < 0.001 | p = 0.163 |
1 | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
2 | 17.7 (7.9; 27.5) | −0.7 (−9.8; 8.3) | 29.1 (13.2; 45.0) | 10.6 (−5.6; 26.8) | 29.9 (13.1; 44.8) | 3.3 (−12.1; 18.8) |
3 | 31.6 (21.7; 41.5) | −8.3 (−18.7; 2.1) | 34.0 (17.9; 50.1) | −3.6 (−22.3; 15.1) | 42.6 (26.5; 58.6) | −13.9 (−31.7; 4.0) |
CRP and IL-6 in the highest tertile | p < 0.001 | p = 0.003 | p = 0.003 | p = 0.089 | p < 0.001 | p = 0.105 |
None | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Only CRP or IL-6 | 21.2 (11.9; 30.6) | −1.9 (−10.7; 6.9) | 24.7 (9.5; 39.9) | −1.6 (− 17.5; 14.2) | 24.8 (9.6; 40.0) | −5.0 (−20.2; 10.2) |
Both CRP and IL-6 | 26.0 (14.9; 37.0) | −20.0 (−31.7; −8.3) | 21.6 (3.7; 39.6) | − 20.0 (−41.2; 1.0) | 36.4 (18.5; 54.3) | −17.5 (− 37.7; 2.8) |
18 and 22 yearsa | ||||||
CRP in the highest tertile | p < 0.001 | p = 0.002 | p = 0.002 | p = 0.455 | p < 0.001 | p = 0.464 |
None | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Only at 18 | 24.3 (12.8; 35.9) | 13.9 (3.0; 24.9) | 25.1 (6.3; 43.9) | 8.8 (−11.0; 28.5) | 30.7 (11.9; 49.5) | 12.9 (−6.0; 31.7) |
Only at 22 | 12.2 (0.52; 23.8) | −6.8 (−18.0; 4.3) | 11.3 (−7.6; 30.1) | −7.8 (−28.0; 12.3) | 20.9 (2.1; 39.8) | 2.7 (−16.5; 21.9) |
Both 18 and 22 years | 31.3 (19.8; 42.8) | −10.0 (−21.6; 1.5) | 32.4 (13.7; 51.0) | −8.6 (−29.5; 12.2) | 40.9 (22.3; 59.5) | −4.3 (− 24.2; 15.6) |
IL-6 in the highest tertile | p < 0.001 | p = 0.306 | p < 0.001 | p = 0.428 | p < 0.001 | p = 0.232 |
None | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Only at 18 | 4.6 (−6.5; 15.7) | 1.9 (−8.4; 12.2) | 10.6 (−7.5; 28.7) | −2.3 (−20.8; 16.1) | 12.2 (−5.6; 30.2) | 3.5 (−14.0; 21.1) |
Only at 22 | 6.1 (−5.1; 17.4) | −9.4 (−20.3; 1.5) | 0.7 (−17.7; 19.1) | − 16.1 (−35.6; 3.4) | 7.6 (− 10.7; 26.0) | −16.5 (− 35.2; 2.2) |
Both 18 and 22 years | 43.5 (31.8; 55.2) | −4.3 (− 16.9; 8.3) | 45.8 (26.8; 64.9) | −1.7 (− 24.3; 21.0) | 57.3 (38.3; 76.3) | −12.3 (− 34.0; 9.4) |
Both CRP and IL-6 in the highest tertile | p < 0.001 | p = 0.001 | p < 0.001 | p = 0.170 | p < 0.001 | p = 0.081 |
None | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
Only at 18 | 30.3 (17.1; 43.45) | 11.6 (−0.3; 23.6) | 40.9 (19.5; 62.3) | 12.7 (−9.0; 34.3) | 48.1 (26.8; 69.4) | 16.7 (−4.0; 37.3) |
Only at 22 | 11.0 (−1.7; 23.7) | −15.5 (−27.9; −3.2) | 5.9 (− 14.7; 26.5) | −16.9 (− 39.2; 5.4) | 24.5 (3.8; 45.1) | −5.6 (− 26.9; 15.7) |
18 and 22 years | 44.6 (27.7; 61.4) | −20.3 (− 38.0; − 2.5) | 42.0 (14.6; 69.4) | − 16.6 (− 48.7; 15.5) | 52.4 (25.1; 79.7) | − 27.3 (− 57.9; 3.3) |