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Table 1 TeMPO Trial Inclusion and Exclusion Criteria

From: The TeMPO trial (treatment of meniscal tears in osteoarthritis): rationale and design features for a four arm randomized controlled clinical trial

Inclusion Criteria
 Age 45–85
 Lives within 60 miles of a clinical site
 English speaking
 Has access to email
 Not living in a nursing home
 Physician suspects meniscal tear with symptoms
 WOMAC* (knee) pain ≥15
 Meniscal tear present on MRI (taken in the last year) and aligning with symptomatic compartment
 Degenerative cartilage changes on MRI (taken in the last year)
Exclusion Criteria
 Equal bilateral symptoms of meniscal tear (in both knees)
 Deemed by physician as “not fit” for a trial of conservative knee treatments due to behavioral or social reasons, being seen for reason other than knee pain, indication for surgery, or contraindication for physical therapy
 Pregnant
 Dementia documented in medical record
 Inflammatory arthritis or avascular necrosis of the knee
 Surgical exclusion (surgery within 6 months on index knee, planned TKR‡ within 6 months, prior knee replacement, or meniscal surgery on index knee)
 Claiming worker’s compensation for knee pain
 Requires use of wheelchair or walker
 Contraindication to or concerning findings on MRI
 Exercise exclusion: physician recommends against unsupervised exercise
 Daily use of strong opioids
 2 deferments due to injection or lack of availability
 Kellgren Lawrence grade 4 osteoarthritis on X-ray
 Currently in a knee physical therapy regimen for 2 weeks or more at a frequency of once a week or more
 Knee pain arising from trauma < 21 days ago
 Physician exclusion (opted out, unfit for trial participation)
  1. * Western Ontario and McMaster Universities Osteoarthritis Index
  2. † Magnetic resonance imaging
  3. ‡ Total knee replacement