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Table 4 Mediation analysis results, including indirect and direct effect for each mode

From: Bone shape mediates the relationship between sex and incident knee osteoarthritis

Mediator effect of mode on sex and incident knee ROA

Indirect effect

Direct effect

OR (95% C.I.)*

p-value

OR (95% C.I.)*

p-value

tibia, mode 1

1.00(0.99,1.00)

0.322

1.50(1.03,2.16)

0.033

tibia, mode 2

0.96(0.91,1.00)

0.043

1.56(1.08,2.27)

0.019

tibia, mode 3

0.99(0.97,1.02)

0.642

1.49(1.03,2.16)

0.033

tibia, mode 4

1.00(1.00,1.00)

0.724

1.49(1.03,2.15)

0.035

tibia, mode 5

0.99(0.99,1.00)

0.207

1.49(1.03,2.16)

0.034

tibia, mode 6

0.99(0.98,1.01)

0.576

1.50(1.04,2.18)

0.030

tibia, mode 7

1.00(0.99,1.02)

0.560

1.48(1.02,2.13)

0.038

tibia, mode 8

1.01(0.99,1.03)

0.533

1.46(1.01,2.12)

0.042

tibia, mode 9

0.99(0.99,1.00)

0.119

1.50(1.04,2.17)

0.032

tibia, mode 10

0.96(0.92,1.00)

0.034

1.53(1.05,2.21)

0.025

tibia, mode 11

0.98(0.94,1.02)

0.246

1.53(1.06,2.22)

0.024

tibia, mode 12

0.99(0.99,1.00)

0.145

1.50(1.04,2.17)

0.032

tibia, mode 13

1.00(1.00,1.00)

0.244

1.49(1.03,2.15)

0.035

femur, mode 1

1.03(0.95,1.12)

0.441

1.44(0.98,2.09)

0.061

femur, mode 2

1.00(0.99,1.01)

0.779

1.47(1.01,2.12)

0.042

femur, mode 3

1.01(0.99,1.03)

0.266

1.45(1.00,2.10)

0.049

femur, mode 4

0.97(0.94,1.00)

0.045

1.50(1.03,2.17)

0.034

femur, mode 5

1.01(0.98,1.04)

0.647

1.47(1.01,2.13)

0.043

femur, mode 6

1.00(1.00,1.00)

0.265

1.46(1.01,2.12)

0.043

femur, mode 7

1.00(0.98,1.01)

0.741

1.47(1.01,2.12)

0.042

femur, mode 8

0.98(0.95,1.02)

0.340

1.50(1.03,2.18)

0.032

femur, mode 9

1.00(1.00,1.00)

0.970

1.46(1.01,2.12)

0.043

femur, mode 10

0.97(0.94,1.00)

0.061

1.50(1.03,2.17)

0.034

femur, mode 11

1.01(1.00,1.01)

0.226

1.46(1.01,2.11)

0.046

femur, mode 12

0.99(0.97,1.01)

0.412

1.47(1.02,2.13)

0.040

femur, mode 13

1.01(0.99,1.02)

0.406

1.46(1.01,2.11)

0.046

  1. Total effect of sex (women vs. men): OR (95% CI)*= 1.49 (1.04, 2.12)
  2. *Adjusting for age, race, clinic site, knee injury and surgery, and BMI
  3. **p-value < 0.05