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Table 4 Mediation analysis results, including indirect and direct effect for each mode

From: Bone shape mediates the relationship between sex and incident knee osteoarthritis

Mediator effect of mode on sex and incident knee ROA Indirect effect Direct effect
OR (95% C.I.)* p-value OR (95% C.I.)* p-value
tibia, mode 1 1.00(0.99,1.00) 0.322 1.50(1.03,2.16) 0.033
tibia, mode 2 0.96(0.91,1.00) 0.043 1.56(1.08,2.27) 0.019
tibia, mode 3 0.99(0.97,1.02) 0.642 1.49(1.03,2.16) 0.033
tibia, mode 4 1.00(1.00,1.00) 0.724 1.49(1.03,2.15) 0.035
tibia, mode 5 0.99(0.99,1.00) 0.207 1.49(1.03,2.16) 0.034
tibia, mode 6 0.99(0.98,1.01) 0.576 1.50(1.04,2.18) 0.030
tibia, mode 7 1.00(0.99,1.02) 0.560 1.48(1.02,2.13) 0.038
tibia, mode 8 1.01(0.99,1.03) 0.533 1.46(1.01,2.12) 0.042
tibia, mode 9 0.99(0.99,1.00) 0.119 1.50(1.04,2.17) 0.032
tibia, mode 10 0.96(0.92,1.00) 0.034 1.53(1.05,2.21) 0.025
tibia, mode 11 0.98(0.94,1.02) 0.246 1.53(1.06,2.22) 0.024
tibia, mode 12 0.99(0.99,1.00) 0.145 1.50(1.04,2.17) 0.032
tibia, mode 13 1.00(1.00,1.00) 0.244 1.49(1.03,2.15) 0.035
femur, mode 1 1.03(0.95,1.12) 0.441 1.44(0.98,2.09) 0.061
femur, mode 2 1.00(0.99,1.01) 0.779 1.47(1.01,2.12) 0.042
femur, mode 3 1.01(0.99,1.03) 0.266 1.45(1.00,2.10) 0.049
femur, mode 4 0.97(0.94,1.00) 0.045 1.50(1.03,2.17) 0.034
femur, mode 5 1.01(0.98,1.04) 0.647 1.47(1.01,2.13) 0.043
femur, mode 6 1.00(1.00,1.00) 0.265 1.46(1.01,2.12) 0.043
femur, mode 7 1.00(0.98,1.01) 0.741 1.47(1.01,2.12) 0.042
femur, mode 8 0.98(0.95,1.02) 0.340 1.50(1.03,2.18) 0.032
femur, mode 9 1.00(1.00,1.00) 0.970 1.46(1.01,2.12) 0.043
femur, mode 10 0.97(0.94,1.00) 0.061 1.50(1.03,2.17) 0.034
femur, mode 11 1.01(1.00,1.01) 0.226 1.46(1.01,2.11) 0.046
femur, mode 12 0.99(0.97,1.01) 0.412 1.47(1.02,2.13) 0.040
femur, mode 13 1.01(0.99,1.02) 0.406 1.46(1.01,2.11) 0.046
  1. Total effect of sex (women vs. men): OR (95% CI)*= 1.49 (1.04, 2.12)
  2. *Adjusting for age, race, clinic site, knee injury and surgery, and BMI
  3. **p-value < 0.05