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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Intervertebral disc degeneration induced by long-segment in-situ immobilization: a macro, micro, and nanoscale analysis

Fig. 2

A. The disc space and T2 signal intensity were measured using radiography and MRI Scans. Radiographs: (a~e) were obtained under anesthesia using a digital, self-contained cabinet x-ray machine (exposure time: 10 s, 26 kV). a (Group A) which served as controls, b~e (Group B~E) as shown in the figure, over time, progressive loss of disc height, d and e more obvious. MRI Scans: (f~j) (Scanning Sequence: FRFSE-XL, Slice thickness:1.4 mm, Interlayer Spacing: 5 mm) uses magnetic waves to create pictures to determine nucleus pulposus size and hydration status according to T2 signal intensity. Over time, the T2 signal intensity progressive decrease, as described above, i and j more serious. The IVD degeneration was classified as grade III. Imm indicates immobilization. B. The intervertebral disc height assessment based on radiographs. In control group (group A), imm-2 weeks (group B), and imm-4 weeks (group C), the intervertebral disc space height was slightly decreased, postoperatively, and this reduction was significant starting at the 6th week (group D). (*) indicates significant difference from other groups discs (p < 0.05)

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