Fig. 2

Pain avoidance behavior tests. a Incapacitance tests were performed and % of weight on the ipsilateral limb was calculated according to the indicated equation. b The time course changes of % weight on the ipsilateral limb was plotted. Asterisk indicated that the values were statistically significant compared to the pre-experimental values. There were 6 samples at each time point. c Mean and standard deviation values in panel B are indicated. Asterisks indicate that the values were statistically significant compared to pre-experimental values. The far right column indicated the p values between the low- and high-dose groups. d Time course changes of paw withdrawal threshold measured using von Frey hairs. Asterisks indicate that the values were statistically significant between ipsilateral side and contralateral side. There were 6 samples in each time point. e Mean and SD values in panel D are indicated. Asterisks indicate that the values were statistically significant compared the pre-experimental values (day 0). The 4th and 6th columns indicate the p values of the ipsilateral and contralateral limbs. The far right column indicates the p values of the low- and high-dose group at each time point