Putative functional variants of lncRNA identified by RegulomeDB were associated with knee osteoarthritis susceptibility

Table 3 Stratified analyses of rs2023843, rs2067051, and rs4378559 genotypes associated with patients of kOA by selected variables

	rs2067051 Additive			rs2067051 TTvs.TC+ CC			rs4378559 Additive			rs2023843 Additive
	OR(95%CI)^a	P ^a	P _het ^b	OR(95%CI)^a	P ^a	P _het ^b	OR(95%CI)^a	P ^a	P _het ^b	OR(95%CI)^a	P ^a	P _het ^b
Age			0.12			0.18			0.17			0.03
age < 60	0.63(0.45–0.89)	0.01		0.41(0.21–0.84)	0.01		1.04(0.68–1.61)	0.86		1.64(1.11–2.44)	0.01
age ≥ 60	0.90(0.68–1.19)	0.47		0.77(0.44–1.33)	0.34		1.56(1.07–2.27)	0.02		0.92(0.65–1.30)	0.63
Gender			0.12			0.01			0.76			0.07
male	1.09(0.70–1.71)	0.69		1.92(0.75–4.91)	0.18		1.36(0.80–2.31)	0.25		1.78(1.09–2.90)	0.02
female	0.73(0.57–0.93)	0.01		0.48(0.29–0.78)	0.00		1.24(0.89–1.72)	0.20		1.05(0.78–1.42)	0.75
BMI			0.43			0.13			0.02			0.55
BMI < 25	0.76(0.57–1.00)	0.05		0.49(0.28–0.87)	0.01		1.02(0.72–1.43)	0.92		1.15(0.84–1.59)	0.38
BMI ≥ 25	0.90(0.64–1.26)	0.54		0.96(0.50–1.86)	0.91		2.07(1.27–3.38)	0.00		1.35(0.90–2.04)	0.15
KL			0.20			0.50			0.17			0.22
KL12	0.70(0.53–0.92)	0.01		0.56(0.32–0.98)	0.04		1.07(0.75–1.52)	0.72		1.41(1.03–1.93)	0.03
KL34	0.89(0.69–1.16)	0.40		0.73(0.44–1.22)	0.23		1.51(1.07–2.11)	0.02		1.07(0.78–1.46)	0.68

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