Results (Combined vs. IV groups) | No.of studies / knee | P | Effect Size | Â | ||
---|---|---|---|---|---|---|
MD/RR | 95% CI | Heterogeneity p (I2) | Model | |||
1. Total blood loss | ||||||
 All studies | 5/651 | 0.0003 | −156.34 | 241.51 to −71.18 | 0.002 (77%) | Random |
Tourniquet or Non-tourniquet | ||||||
 Tourniquet | 3/471 | 0.05 | − 108.68 | − 217.44 to 0.08 | 0.005 (81%) | Random |
 Non-tourniquet | 2/179 | 0.0008 | − 251.30 | −398.40 to − 104.19 | 0.17 (47%) | Fixed |
Topical TXA dose | Â | Â | Â | Â | Â | Â |
 ≤ 1.5 g | 2/284 | 0.10 | −54.93 | −119.43 to 9.57 | 0.33 (0%) | Fixed |
 >1.5 g | 3/367 | <  0.00001 | − 209.39 | − 255.95 to − 162.83 | 0.36 (1%) | Fixed |
Number of IV TXA | Â | Â | Â | Â | Â | Â |
 Single dose | 2/244 | 0.13 | −210.91 | − 485.30 to 63.47 | 0.03 (80%) | Random |
 ≥ 2 doses | 3/407 | 0.005 | − 147.43 | −251.16 to −43.69 | 0.002 (84%) | Random |
2. Maximum hemoglobin drop | ||||||
 All studies | 4/591 | 0.003 | −0.56 | −0.93 to −0.19 | <  0.00001 (90%) | Random |
Tourniquet or Non-tourniquet | ||||||
 Tourniquet | 3/472 | 0.05 | −0.52 | −1.04 to 0.00 | <  0.00001 (92%) | Random |
 Non-tourniquet | 1/119 | <  0.00001 | −0.68 | − 0.88 to − 0.48 | – | – |
Topical TXA dose | ||||||
 ≤ 1.5 g | 2/284 | 0.006 | −0.21 | −0.35 to − 0.06 | 0.17 (47%) | Fixed |
 >1.5 g | 2/307 | <  0.00001 | −0.78 | −0.99 to − 0.56 | 0.17 (47%) | Fixed |
Number of IV TXA | Â | Â | Â | Â | Â | Â |
 Single dose | 1/184 | 0.03 | −0.17 | −0.33 to − 0.01 | – | – |
 ≥ 2 doses | 3/407 | <  0.00001 | −0.73 | −0.93 to − 0.54 | 0.21 (36%) | Fixed |
3. Transfusion requirements | ||||||
 All studies | 5/651 | 0.19 | 0.48 | 0.16 to 1.44 | 0.69 (0%) | Fixed |
Tourniquet or Non-tourniquet | ||||||
 Tourniquet | 3/472 | 0.70 | 0.75 | 0.17 to 3.26 | – | – |
 Non-tourniquet | 2/179 | 0.16 | 0.28 | 0.05 to 1.64 | 0.89 (0%) | Fixed |
Topical TXA dose | ||||||
 ≤ 1.5 g | 3/344 | 0.50 | 0.64 | 0.17 to 2.37 | 0.65 (0%) | Fixed |
 >1.5 g | 2/307 | 0.21 | 0.25 | 0.03 to 2.21 | – | – |
Number of IV TXA | ||||||
 Single dose | 2/244 | 0.50 | 0.64 | 0.17 to 2.37 | 0.65 (0%) |  |
 ≥ 2 doses | 3/407 | 0.21 | 0.25 | 0.03 to 2.21 | – | – |
4. Drainage volume | 3/334 | 0.0004 | −43.54 | −67.59 to −19.48 | 0.34 (7%) | Fixed |
5. DVT | 6/701 | 0.99 | 1.01 | 0.14 to 7.12 | 0.34 (0%) | Fixed |