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Table 1 Characteristics of included studies

From: The efficacy and safety of combined administration of intravenous and topical tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials

Author Diagnose No. Of patients Age (years) Interventions Drainage Tourniquet Transfusion criteria DVT prophylaxis DVT screen
Huang [16] OA VI: 92 VI: 64.7 VI: 3 g used before inflation Yes Yes 70 g/L ≤ Hb ≤ 90 g/L with anemia, Hb ≤70 g/L LMWH Rivaroxaban Ultrasound
  Combined: 92 Combined: 65.4 Combined:1.5 g used intravenously before inflation + 1.5 g used topically      
Jain [17] OA VI:60 VI: 70.0 VI: 15 mg/kg 30 min before skin incision, 10 mg/kg was repeated 3 and 6 h later. No No 7.0 g/d L ≤ Hb ≤ 8.0 g/dL with symptomatic anemia or Hb ≤7.0 g/dL Aspirin Clinical+ ultrasound
  Combined:59 Combined: 68.27 Combined: Same IV dose + 2 g used before closure of arthrotomy      
Nielsen[22] NS VI:30 VI: 63.2 VI: 1 g used + 100 mL of saline used after closure of the capsule No No Hb < 7.5 g/dL or < 10 g/dL with heart disease or Hb reduced > 25% Rivaroxaban Clinical
  Combined:30 Combined: 65.5 Combined: same IV dose+ 3 g used after closure of the capsule      
Lee [23] OA VI:93 VI: 73.4 VI: 10 mg/kg 30 min before deflation, same dose repeated 3 h later Yes Yes 7.0 g/dL ≤ Hb ≤ 8.0 g/dL with symptomatic anemia or Hb ≤7.0 g/dL Rivaroxaban, Aspirin Clinical +CT
  Combined:95 Combined: 72.1 Combined: 10 mg/kg 30 min before deflation, same dose repeated 3 h later + 2 g injected.      
Song [24] OA VI:50 VI: 69.2 VI: 10 mg/kg 20 min before inflation,10 mg/kg 15 min before deflation, and 10 mg/kg 3 h later. Yes Yes Hb < 8 g/% LMWH Ultrasound + CT
  Combined:50 Combined: 70.8 Combined: Same IV dose + 1.5 g used topically after wound closure      
Liu [19] OA VI:25 VI: NS VI: 1 g 10 min before inflation Yes Yes Hb ≤8 g/dL Rivaroxaban Ultrasound
  Combined:25 Combined: NS Combined: same VI dose + 1 g 10 min before inflation      
  1. Abbreviation: OA osteoarthritis, VI intravenous, NS not stated, DVT deep venous thrombosis, Hb hemoglobin, LMWH low-molecular weight heparin, CT computed tomographic