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Table 1 Characteristics of included studies

From: The efficacy and safety of combined administration of intravenous and topical tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled trials

Author

Diagnose

No. Of patients

Age (years)

Interventions

Drainage

Tourniquet

Transfusion criteria

DVT prophylaxis

DVT screen

Huang [16]

OA

VI: 92

VI: 64.7

VI: 3 g used before inflation

Yes

Yes

70 g/L ≤ Hb ≤ 90 g/L with anemia, Hb ≤70 g/L

LMWH Rivaroxaban

Ultrasound

 

Combined: 92

Combined: 65.4

Combined:1.5 g used intravenously before inflation + 1.5 g used topically

     

Jain [17]

OA

VI:60

VI: 70.0

VI: 15 mg/kg 30 min before skin incision, 10 mg/kg was repeated 3 and 6 h later.

No

No

7.0 g/d L ≤ Hb ≤ 8.0 g/dL with symptomatic anemia or Hb ≤7.0 g/dL

Aspirin

Clinical+ ultrasound

 

Combined:59

Combined: 68.27

Combined: Same IV dose + 2 g used before closure of arthrotomy

     

Nielsen[22]

NS

VI:30

VI: 63.2

VI: 1 g used + 100 mL of saline used after closure of the capsule

No

No

Hb < 7.5 g/dL or < 10 g/dL with heart disease or Hb reduced > 25%

Rivaroxaban

Clinical

 

Combined:30

Combined: 65.5

Combined: same IV dose+ 3 g used after closure of the capsule

     

Lee [23]

OA

VI:93

VI: 73.4

VI: 10 mg/kg 30 min before deflation, same dose repeated 3 h later

Yes

Yes

7.0 g/dL ≤ Hb ≤ 8.0 g/dL with symptomatic anemia or Hb ≤7.0 g/dL

Rivaroxaban, Aspirin

Clinical +CT

 

Combined:95

Combined: 72.1

Combined: 10 mg/kg 30 min before deflation, same dose repeated 3 h later + 2 g injected.

     

Song [24]

OA

VI:50

VI: 69.2

VI: 10 mg/kg 20 min before inflation,10 mg/kg 15 min before deflation, and 10 mg/kg 3 h later.

Yes

Yes

Hb < 8 g/%

LMWH

Ultrasound + CT

 

Combined:50

Combined: 70.8

Combined: Same IV dose + 1.5 g used topically after wound closure

     

Liu [19]

OA

VI:25

VI: NS

VI: 1 g 10 min before inflation

Yes

Yes

Hb ≤8 g/dL

Rivaroxaban

Ultrasound

 

Combined:25

Combined: NS

Combined: same VI dose + 1 g 10 min before inflation

     
  1. Abbreviation: OA osteoarthritis, VI intravenous, NS not stated, DVT deep venous thrombosis, Hb hemoglobin, LMWH low-molecular weight heparin, CT computed tomographic