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Table 1 Clinical features in 27 cases of secondary syphilis with long bones of the limbs involvement [6, 13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31]

From: The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review

Parameter No. (%) of Patients
Demographic
 Male sex 21/27 (78%)
 Age, median (range), year 32 (12–64)
 HIV infection 10/27 (37%)
Clinical findings
 Bone pain 27/27 (100%)
 Recent history of genital ulcer 3/27 (11%)
 Rash 14/27 (52%)
 Generalised lymphadenopathy 7/27 (26%)
General manifestations
 Fever 9/27 (33%)
 Sweating 6/27 (22%)
 Loss of appetite 5/27 (19%)
 Loss of weight 8/27 (30%)
 Increased bone pain at night 10/27 (37%)
Positive serologic test for syphilis
 Nontreponemal test (Kolmer, VDRL, RPR) 27/27 (100%)
 VDRL titre, median (range)a 1:32 (1:8–1:320)
 RPR titre, median (range)b 1:128 (1:16–1:512)
 FTA-ABS 10/10 (100%)
 MHA-TP/TPHA/TPPA 14/14 (100%)
Sites of affected long bones of the limbs
 Tibia 25/27 (93%)
 Fibula 11/27 (41%)
 Ulna 8/27 (30%)
 Radius 5/27 (19%)
 Humerus 5/27 (19%)
 Femur 5/27 (19%)
Imaging findings
 Abnormal plain x-ray 13/22 (59%)
 Abnormal bone scintigraphy 20/20 (100%)
 Abnormal CT or/and MRI 4/4 (100%)
 Multifocal bone involvement 22/27 (81%)
 Destructive bone lesions 8/27 (30%)
Histologic findings of bone biopsy
 Plasma cell or/and lymphocyte infiltrations 5/8 (63%)
T. pallidum detectionc 4/8 (50%)
Antibiotic treatment
 Benzathine penicillin G 12/27 (44%)
 Penicillin G 9/27 (33%)
 Procaine penicillin G 4/27 (15%)
 Doxycycline 2/27 (7%)
 Azithromycin 1/27 (4%)
 Cephaloridine 1/27 (4%)
 Nafcillin 1/27 (4%)
 Ceftriaxone 1/27 (4%)
  1. aDetermined in 15 patients
  2. bDetermined in 8 patients
  3. cT. pallidum was detected by dark-field microscope (n = 1), silver stain (n = 3)