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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: Effects of controlled abnormal joint movement on the molecular biological response in intra-articular tissues during the acute phase of anterior cruciate ligament injury in a rat model

Fig. 4

Gene expression at days 1, 3, and 5 after surgery. Expression levels of matrix metalloproteinase-13 (MMP-13) in the anterior cruciate ligament (ACL, a), medial meniscus (b), and lateral meniscus (c). MMP-13 expression in the ACL and medial meniscus differed significantly between the ACL-T and CAM groups. The expression levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the ACL (d), medial meniscus (e), and lateral meniscus (f). TIMP-1 in all intra-articular tissues was not significantly different between the ACL-T and CAM groups. MMP-13/TIMP-1 ratios in the ACL (g), the medial meniscus (h), and the lateral meniscus (i). The ACL-T and CAM groups significantly differed with respect to the MMP-13/TIMP-1 ratio in the ACL and the medial meniscus on days 1 and 5 after surgery. On the other hand, in the lateral meniscus, the MMP-13/TIMP-1 ratio was significantly higher for the ACL-T group than for the other groups, with no significant difference between the CAM group and the SO and IN groups. ACL-T, ACL-transection; CAM, controlled abnormal movement; SO, sham operated, * p < 0.001 compared with day 1, † p < 0.001 compared with the ACL-T and CAM groups. Data showed mean ± standard deviation

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