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Table 2 Meta-analyses of BMD of the different regions of knee at different time points

From: Effect of bisphosphonates on periprosthetic bone loss after total knee arthroplasty: a meta-analysis of randomized controlled trials

ROI 3 months 6 months 12 months
WMD (95%CI) WMD (95%CI) WMD (95%CI)
Tibia 1 4.90 (3.53, 6.26) 6.63 (5.34, 7.93) 4.22 (2.92, 5.51)
P < 0.05 P < 0.05 P < 0.05
2 2.61 (1.32, 3.91) 5.86 (4.57, 7.16) 8.57 (7.28, 9.87)
P < 0.05 P < 0.05 P < 0.05
3 1.10 (−0.19, 2.40) 0.45 (− 0.84, 1.75) 0.36 (0.94, 1.65)
P = 0.18 P = 0.39 P = 0.44
Femur 4 4.10 (2.74, 5.46) 4.50 (3.13, 5.86) 5.70 (4.34, 7.06)
P < 0.05 P < 0.05 P < 0.05
5 6.90 (5.54, 8.27) 6.50 (5.14, 7.87) 7.02 (5.66, 8.39)
P < 0.05 P < 0.05 P < 0.05
6 4.34 (2.97, 5.70) 4.32 (2.96, 5.68) 5.25 (3.89, 6.62)
P < 0.05 P < 0.05 P < 0.05
  1. ROI: region of interest, WMD: weighted mean differences
  2. A positive value of WMD means it favors experimental, and negative value means favoring control