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Table 2 Meta-analyses of BMD of the different regions of knee at different time points

From: Effect of bisphosphonates on periprosthetic bone loss after total knee arthroplasty: a meta-analysis of randomized controlled trials

ROI

3 months

6 months

12 months

WMD (95%CI)

WMD (95%CI)

WMD (95%CI)

Tibia

1

4.90 (3.53, 6.26)

6.63 (5.34, 7.93)

4.22 (2.92, 5.51)

 P < 0.05

 P < 0.05

 P < 0.05

2

2.61 (1.32, 3.91)

5.86 (4.57, 7.16)

8.57 (7.28, 9.87)

 P < 0.05

 P < 0.05

 P < 0.05

3

1.10 (−0.19, 2.40)

0.45 (− 0.84, 1.75)

0.36 (0.94, 1.65)

 P = 0.18

 P = 0.39

 P = 0.44

Femur

4

4.10 (2.74, 5.46)

4.50 (3.13, 5.86)

5.70 (4.34, 7.06)

P < 0.05

 P < 0.05

 P < 0.05

5

6.90 (5.54, 8.27)

6.50 (5.14, 7.87)

7.02 (5.66, 8.39)

 P < 0.05

 P < 0.05

 P < 0.05

6

4.34 (2.97, 5.70)

4.32 (2.96, 5.68)

5.25 (3.89, 6.62)

 P < 0.05

 P < 0.05

 P < 0.05

  1. ROI: region of interest, WMD: weighted mean differences
  2. A positive value of WMD means it favors experimental, and negative value means favoring control