Calcifediol (25-hydroxyvitamin D) improvement and calcium-phosphate metabolism of alendronate sodium/vitamin D3 combination in Chinese women with postmenopausal osteoporosis: a post hoc efficacy analysis and safety reappraisal

Table 2 Calcium-phosphate metabolism-associated AEs

n (%)	ALN/D5600 (n = 107)	Calcitriol (n = 108)	P-value
Hypercalcemia	0 (0.0)	1 (0.9)	0.84
Hyperphosphatemia	3 (2.8)	1 (0.9)	0.31
Hypercalciuria at 6 months	10 (9.4)	20 (18.5)	0.05
Hypercalciuria at 12 months	13 (12.3)	14 (13.0)	0.86

Hypercalcemia was defined as serum calcium > 2.60 mmol/L; hyperphosphatemia was defined as serum phosphate > 1.46 mmol/L with an increase of > 20% from baseline; hypercalciuria was defined as 24-h urine calcium > 7.5 mmol/L with an increase of > 25% from baseline. Data were analyzed in the APaT (all patients, as treated) population

ISSN: 1471-2474