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Table 3 PK parameters of DF after single IA administration of SI-613 in rabbits with antigen-induced arthritis

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

  Cmax (ng/g) Tmax (day) AUC0-28day (ng∙day/g) AUC0-∞ (ng∙day/g) t1/2 (day)
Synovium 311.6 1 1336 1487 10.8a
  Cmax (ng/joint) Tmax (day) AUC0-21day (ng∙day/joint) AUC0-∞ (ng∙day/joint) t1/2 (day)
Synovial lavage fluid 4726 1 7956 8018 7.7b
  1. SI-613 was intra-articularly injected at a dose of 5 mg/joint. The PK parameters were calculated from mean concentrations of DF in synovium or mean amounts of DF in joint cavity (n = 3)
  2. a, Calculated from 14 to 28 days after administration
  3. b, Calculated from 7 to 21 days after administration