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Table 2 Plasma DF concentrations of rabbits with antigen-induced arthritis

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Group Cmax
(ng/mL)
Tmax
(h)
AUC0-t
(ng·h/mL)
AUC0-∞
(ng·h/mL)
t1/2
(h)
DF-Na (oral) 621.0 ± 371.6 2.4 ± 3.2 4693 ± 1905 4132b 12.8b
Mixturea 125.9 ± 68.5 0.39 ± 0.53 393.4 ± 167.6 423.2 ± 154.5 3.4 ± 2.0
SI-613 (IA) 1.343 ± 0.050 24 ± 0 25.11b NC NC
  1. Mean ± SD (n = 3 or n = 2) calculated from the individual PK parameters
  2. NC Not calculated.
  3. BLQ: < 1 ng/mL
  4. a a mixture of DF-Na and HA (IA)
  5. b n = 2