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Table 2 Plasma DF concentrations of rabbits with antigen-induced arthritis

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Group

Cmax

(ng/mL)

Tmax

(h)

AUC0-t

(ng·h/mL)

AUC0-∞

(ng·h/mL)

t1/2

(h)

DF-Na (oral)

621.0 ± 371.6

2.4 ± 3.2

4693 ± 1905

4132b

12.8b

Mixturea

125.9 ± 68.5

0.39 ± 0.53

393.4 ± 167.6

423.2 ± 154.5

3.4 ± 2.0

SI-613 (IA)

1.343 ± 0.050

24 ± 0

25.11b

NC

NC

  1. Mean ± SD (n = 3 or n = 2) calculated from the individual PK parameters
  2. NC Not calculated.
  3. BLQ: < 1 ng/mL
  4. a a mixture of DF-Na and HA (IA)
  5. b n = 2
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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