Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Table 1 DF concentrations in the synovium and synovial joint cavity of rabbits with antigen-induced arthritis

Group	Sampling point	Animal Number	Concentration of DF
Group	Sampling point	Animal Number	Synovium (ng/g tissue)	Synovial lavage fluid (ng/mL fluid)
DF-Na (oral)	3 h	1	155.8	124.6
		2	52.88	58.23
		3	75.83	45.66
	72 h	4	BLQ1	BLQ2
		5	BLQ1	BLQ2
		6	BLQ1	BLQ2
A mixture of DF-Na and HA (IA)	72 h	1	BLQ1	BLQ2
		2	BLQ1	BLQ2
		3	48.02	21.70
SI-613 (IA)	72 h	1	15.23	60.64
		2	45.47	38.82
		3	351.1	1540

ISSN: 1471-2474