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Table 1 DF concentrations in the synovium and synovial joint cavity of rabbits with antigen-induced arthritis

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Group Sampling point Animal Number Concentration of DF
Synovium (ng/g tissue) Synovial lavage fluid (ng/mL fluid)
DF-Na (oral) 3 h 1 155.8 124.6
2 52.88 58.23
3 75.83 45.66
72 h 4 BLQ1 BLQ2
5 BLQ1 BLQ2
6 BLQ1 BLQ2
A mixture of DF-Na and HA (IA) 72 h 1 BLQ1 BLQ2
2 BLQ1 BLQ2
3 48.02 21.70
SI-613 (IA) 72 h 1 15.23 60.64
2 45.47 38.82
3 351.1 1540
  1. BLQ1: below limit of quantification, < 5 ng/g
  2. BLQ2: < 1 ng of DF per mL of synovial lavage fluid