Skip to main content

Advertisement

Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Fig. 5

Effects of SI-613 on PGE2 content in the synovial fluid of antigen-induced arthritis in rabbits. Two days after the induction of arthritis, the test materials were administered. The synovial fluid (SF) was collected at 3 (a) or 72 (b) hours after the administration of the test materials. The prostaglandin E2 (PGE2) content in the SF was measured with a PGE2 enzyme-linked immunosorbent assay (ELISA) kit. For statistical analysis, a Student’s t-test and Tukey’s test were used for the 3 h and 72 h data, respectively. a ***p < 0.001 (vs. control, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals. (n = 10 per group, except for the normal group n = 5) (b) ***p < 0.001 (vs. SI-613, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals. (n = 10 per group, except for the normal group n = 5)

Back to article page