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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Fig. 4

Effects of SI-613 on PGE2 content in the synovial fluid of silver nitrate-induced arthritic rats. Silver nitrate-induced arthritic rats given 0.5 mg SI-613 or vehicle intra-articularly were evaluated for pain score (a), and sacrificed for measurement of the prostaglandin E2 (PGE2) content in the SF (b) on days 1, 2, and 3. For statistical analysis of pain score, Wilcoxon test was used. **p < 0.01, *p < 0.05 (vs. control, significant level at 5%, two-tailed). For statistical analysis of the PGE2 content, Welch’s t-test was used. ##p < 0.01 (vs. control, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals [n = 6 per group, except for the normal group (PGE2 content) n = 7]

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