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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Pharmacological effects of N-[2-[[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]ethyl]hyaluronamide (diclofenac Etalhyaluronate, SI-613), a novel sodium hyaluronate derivative chemically linked with diclofenac

Fig. 3

Analgesic effects of SI-613 and its chemical compositions in silver nitrate-induced arthritic pain model in rats. Silver nitrate-induced arthritic rats given SI-613 (closed circle), HA (open triangle), DF-Na + HA (closed triangle), or vehicle (open circle) intra-articularly; those given DF-Na orally once daily for 3 days (open square); and non-treated normal rats (closed square) were evaluated for pain score (a) and weight-bearing rate (b) over time. Mean values of pain scores (c) and weight-bearing rate (d) for 3 days were calculated and subjected to statistical analysis: two-way analyses of variance followed by Tukey’s test. ***p < 0.001 (vs. SI-613, significant level at 5%, two-tailed). Values represent the means ±95% confidence intervals (n = 9 per group, except for the normal group n = 3)

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