Table 1 Baseline characteristics
From: A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride
Variable | Dutasteride users (n = 31,615) | Finasteride users (n = 31,615) | Standardized Difference |
|---|---|---|---|
Age (median, IQR) | 75 (71–81) | 75 (71–81) | 0.00 |
 66–74 | 15,221 (48.1%) | 15,150 (47.9%) | 0.00 |
 75–84 | 12,940 (40.9%) | 13,031 (41.2%) | 0.01 |
 85+ | 3454 (10.9%) | 3434 (10.9%) | 0.00 |
Charlson Co-morbidity Index, No. (%) (2Â years hospitalization data) | |||
 No hospitalization | 23,643 (74.8%) | 23,547 (74.5%) | 0.01 |
 0 | 3365 (10.6%) | 3241 (10.3%) | 0.01 |
 1 | 1740 (5.5%) | 1785 (5.6%) | 0.01 |
 2 + | 2867 (9.1%) | 3042 (9.6%) | 0.02 |
Number of prescription medications in previous year (median, IQR) | 8 (4–11) | 8 (4–11) | 0.00 |
Residence in a long-term care facility, No. (%) | 592 (1.9%) | 724 (2.3%) | 0.03 |
Medication use in previous 365Â days, No. (%) | |||
 Oral corticosteroid | 1562 (4.9%) | 1696 (5.4%) | 0.02 |
 Testosterone | 357 (1.1%) | 265 (0.8%) | 0.03 |
 Tenofovir | 6 (0.0%) | 14 (0.0%) | 0.01 |
 Thyroid hormone | 2452 (7.8%) | 2409 (7.6%) | 0.01 |
 Alpha-adrenergic blocker | 5630 (17.8%) | 6156 (19.5%) | 0.04 |
 Anticonvulsants | 416 (1.3%) | 477 (1.5%) | 0.02 |
 Tricyclic antidepressants | 1167 (3.7%) | 1213 (3.8%) | 0.01 |
 Selective serotonin reuptake inhibitors | 2465 (7.8%) | 2561 (8.1%) | 0.01 |
 Other antidepressants | 13,798 (43.6%) | 13,024 (41.2%) | 0.05 |
 Antipsychotics | 859 (2.7%) | 948 (3.0%) | 0.02 |
 Loop diuretics | 3257 (10.3%) | 3334 (10.5%) | 0.01 |
 Thiazide diuretics | 5930 (18.8%) | 5727 (18.1%) | 0.02 |
 Thiazolidinediones | 628 (2.0%) | 684 (2.2%) | 0.01 |
 Proton pump inhibitors | 8439 (26.7%) | 8386 (26.5%) | 0.00 |
 Benzodiazepines | 5131 (16.2%) | 4987 (15.8%) | 0.01 |
Previous diagnoses, No. (%) | |||
 Myocardial infarction | 2325 (7.4%) | 2440 (7.7%) | 0.01 |
 Diabetes | 9531 (30.1%) | 9647 (30.5%) | 0.01 |
 Asthma | 3678 (11.6%) | 3641 (11.5%) | 0.00 |
 Congestive heart failure | 3675 (11.6%) | 3855 (12.2%) | 0.02 |
 Chronic obstructive pulmonary disease | 7717 (24.4%) | 7601 (24.0%) | 0.01 |
 Dementia | 3445 (10.9%) | 3639 (11.5%) | 0.02 |
 Chronic kidney disease | 1798 (5.7%) | 1931 (6.1%) | 0.02 |
 Rheumatoid arthritis | 94 (0.3%) | 117 (0.4%) | 0.01 |
 Systemic lupus erythematosus | 1888 (6.0%) | 1954 (6.2%) | 0.01 |
Medical conditions in previous 2Â years, No. (%) | |||
 Alcohol abuse | 327 (1.0%) | 384 (1.2%) | 0.02 |
 Stroke or transient ischemic attack | 545 (1.7%) | 583 (1.8%) | 0.01 |
Prescribing physician, No. (%) | |||
 Family physician | 8924 (28.2%) | 13,553 (42.9%) | 0.31 |
 Urologist | 16,862 (53.3%) | 11,402 (36.1%) | 0.35 |
 Other | 1106 (3.5%) | 1543 (4.9%) | 0.07 |
 Unknown | 4723 (14.9%) | 5117 (16.2%) | 0.03 |
Specialist in preceding year, No. (%) | |||
 Nephrologist | 2249 (7.1%) | 2484 (7.9%) | 0.03 |
 Endocrinologist | 1973 (6.2%) | 1615 (5.1%) | 0.05 |
 Geriatrician | 1191 (3.8%) | 1389 (4.4%) | 0.03 |
Income Quintile, No. (%) | |||
 1 (lowest) | 5273 (16.7%) | 5265 (16.7%) | 0.00 |
 2 | 6123 (19.4%) | 6183 (19.6%) | 0.00 |
 3 | 6178 (19.5%) | 6245 (19.8%) | 0.01 |
 4 | 6711 (21.2%) | 6746 (21.3%) | 0.00 |
 5 (highest) | 7217 (22.8%) | 7062 (22.3%) | 0.01 |
 Missing | 113 (0.4%) | 114 (0.4%) | 0.00 |