Association between Fas/FasL gene polymorphism and musculoskeletal degenerative diseases: a meta-analysis

Table 1 Main Characteristics of Studies Included in This Meta-analysis

Study ID	Year	Enrolled Country	Ethnicity	Age Range	Gender	Diagnosis	Diagnosis by	Genotyping Method	Control Source	Matching	Cases	Controls
Lv et al. [32]	2009	China	Chinese	N/D	N/D	IVDD	N/D	PCR-seq	N/D	N/D	223	124
Zhu et al. [24]	2011	China	Chinese	30–68	both	IVDD	MRI	PCR-seq	healthy subjects	age, sex, occupation, smoking	348	215
Sun et al. [19]	2013	China	Chinese	N/D^&	both	IVDD	MRI	PCR-seq	participants with nonspine-related problems	age, sex, race	472	528
Zhang et al. [23]	2013	China	Chinese	33–61	both	IVDD	MRI	PCR-seq	patients or participants without back pain	race, sex, age, living areas	129	132
Sezgin et al. [22]	2013	Turkey	Caucasoid	43–70	both	OA	ACR	PCR-seq	patients without OA related disease	N/D	148	102
Coakley et al. [25]	1999	UK	Caucasoid	24–87	both	RA	ACR	PCR-seq	healthy subjects	age	18	128
Huang et al. [26]	1999	Australia	Caucasoid	23–65	both	RA	ARA	PCR-seq	healthy subjects	N/D	185	86
Lee et al. [28]	2001	Korea	Korean	16–75	both	RA	ACR	PCR-seq	healthy subjects	ethnically	87	87
Mohammad- zadeh et al. [29]	2012	Iran	Caucasoid	28–59	both	RA	N/D	PCR-seq	healthy subjects	N/D	120	112
Kobak et al. [27]	2012	Turkey	N/D	19–72	both	RA	ACR	PCR-seq	healthy subjects	age, sex	101	105
Seyfi et al. [30]	2013	Turkey	Caucasoid	20–80	both	RA	ACR	PCR-seq	patients without musculoskeletal diseases	age,sex, ethnically	100	101
Zhu et al. [31]	2016	China	Chinese	40–70	both	RA	ACR	N/D	patients without RA	age, sex	839	615

Abbreviations: ACR the American college of rheumatology diagnostic criteria for RA, ARA American rheumatology association 1987 criteria, IVDD Intervertebral disc degeneration, OA osteoarthritis, RA rheumatoid arthritis, N/D not described, PCR-seq restriction analysis polymerase chain reaction sequencing. &, the author only mentioned the mean ages of the case and control groups were 36.5 and 38.7 years, respectively

ISSN: 1471-2474